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Literature summary for 3.4.22.38 extracted from
- Inhibition of Ulmus davidiana Planch (Ulmaceae) on bone resorption mediated by processing of cathepsin K in cultured mouse osteoclasts (2008), Phytother. Res., 22, 511-517.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| E64 | a nonselective cysteine protease inhibitor, complete inhibition | Mus musculus |  |
| additional information | stem bark extracts of Ulmus davidiana, a deciduous tree from Korea and an antiinflammatory in traditional Korean medicine, prevents the osteoclast-mediated intracellular processing of Cat K, suggesting that it may disrupt the intracellular transport of pro Cat K. Ulmus davidiana dose-dependently inhibits in vitro bone resorption with a potency similar to that observed for inhibition of Cat K processing | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lysosome | - |
Mus musculus | 5764 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 32000 | - |
x * 32000, about, proenzyme | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | Cat K plays a key role in matrix degradation during bone resorption | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | processing of the proenzyme for activation involving reentry and delivery of proenzyme into lysosome which is enhanced by mannose-6-phosphate and mediated by the mannose-6-phosphate receptor, overview | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cell culture | - |
Mus musculus | - |
| long bone | - |
Mus musculus | - |
| osteoblast | - |
Mus musculus | - |
| osteoclast | - |
Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
osteoclast resorption activity | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| carbobenzyloxy-Leu-Arg-4-methoxy-2-naphthylamide + H2O | - |
Mus musculus | carbobenzyloxy-Leu-Arg + 4-methoxy-2-naphthylamine | - |
? | |
| additional information | Cat K plays a key role in matrix degradation during bone resorption | Mus musculus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 32000, about, proenzyme | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Cat K | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Mus musculus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| additional information | - |
Ulmus diviana stem bral extracts show an IC50 of 0.0875 mg/ml | Mus musculus | additional information |
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Release 2023.1 (January 2023)
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