Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-(1-([(cyanomethyl)amino]carbonyl)cyclohexyl)-4-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide | i.e. L-006235 or CRA-013788/L | Homo sapiens | |
N-(1-([(cyanomethyl)amino]carbonyl)cyclohexyl)-4-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide | i.e. L-006235 or CRA-013788/L | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
collagen I + H2O | Homo sapiens | - |
? | - |
? | |
collagen I + H2O | Mus musculus | inhibition of cathepsin K reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice, overview | ? | - |
? | |
collagen I + H2O | Mus musculus DBA/1J | inhibition of cathepsin K reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
DBA/1J mice | - |
Mus musculus DBA/1J | - |
DBA/1J mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone | - |
Mus musculus | - |
bone | - |
Homo sapiens | - |
osteoclast | - |
Mus musculus | - |
osteoclast | - |
Homo sapiens | - |
synovial fibroblast | - |
Mus musculus | - |
synovial fibroblast | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
collagen I + H2O | - |
Mus musculus | ? | - |
? | |
collagen I + H2O | - |
Homo sapiens | ? | - |
? | |
collagen I + H2O | inhibition of cathepsin K reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice, overview | Mus musculus | ? | - |
? | |
collagen I + H2O | - |
Mus musculus DBA/1J | ? | - |
? | |
collagen I + H2O | inhibition of cathepsin K reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice, overview | Mus musculus DBA/1J | ? | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000000073 | - |
N-(1-([(cyanomethyl)amino]carbonyl)cyclohexyl)-4-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide | recombinant cathepsin K | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000024 | - |
recombinant cathepsin K | Mus musculus | N-(1-([(cyanomethyl)amino]carbonyl)cyclohexyl)-4-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide | |
0.000028 | - |
at the cellular level in human osteoclasts | Homo sapiens | N-(1-([(cyanomethyl)amino]carbonyl)cyclohexyl)-4-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide |