Protein Variants | Comment | Organism |
---|---|---|
additional information | 10-week-old male cathepsin K-deficient knockout mice show bones that are mechanically more brittle, while both osteoclasts and osteoblasts show impaired activity relative to the wild type, phenotype with significant hypercalcification of the calcified cartilage and cortices, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cathepsin K inhibitor II | - |
Mus musculus | |
additional information | no inhibition of cathepsin K inhibitor III | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Mus musculus | 5764 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | cathepsin K plays a role in bone tissue development as well as skeletal remodeling, overview | ? | - |
? | |
additional information | Mus musculus C57Bl6/J | cathepsin K plays a role in bone tissue development as well as skeletal remodeling, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57Bl6/J mice | - |
Mus musculus C57Bl6/J | - |
C57Bl6/J mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone | - |
Mus musculus | - |
bone cancer cell | skeletal and nonskeletal tumor cell | Mus musculus | - |
chondroclast | - |
Mus musculus | - |
chondrocyte | - |
Mus musculus | - |
endothelial cell | - |
Mus musculus | - |
gastric cancer cell | - |
Mus musculus | - |
osteoblast | - |
Mus musculus | - |
osteoclast | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | cathepsin K plays a role in bone tissue development as well as skeletal remodeling, overview | Mus musculus | ? | - |
? | |
additional information | cathepsin K plays a role in bone tissue development as well as skeletal remodeling, overview | Mus musculus C57Bl6/J | ? | - |
? |