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Literature summary for 3.4.22.38 extracted from

  • Kozloff, K.M.; Quinti, L.; Patntirapong, S.; Hauschka, P.V.; Tung, C.H.; Weissleder, R.; Mahmood, U.
    Non-invasive optical detection of cathepsin K-mediated fluorescence reveals osteoclast activity in vitro and in vivo (2009), Bone, 44, 190-198.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.38

Activating Compound

Activating Compound Comment Organism Structure
additional information cathepsin K is activated by proteolytic cleavage Mus musculus
additional information cathepsin K is activated by proteolytic cleavage Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1,3-bis(CBZ-Leu-NH)-2-propanone
-
 Homo sapiens
1,3-bis(CBZ-Leu-NH)-2-propanone
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secereted by osteoclasts Mus musculus
-
-
extracellular the enzyme is secereted by osteoclasts Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
collagen I + H2O Mus musculus osteoclasts degrade bone matrix by demineralization followed by degradation of type I collagen through secretion of the cysteine protease, cathepsin K ?
-
 ?
collagen I + H2O Homo sapiens osteoclasts degrade bone matrix by demineralization followed by degradation of type I collagen through secretion of the cysteine protease, cathepsin K ?
-
 ?
additional information Mus musculus media from cells on plastic show higher CatK activation than cells on dentin, consistent with cellular expression of cathepsin K mRNA, 2fold upregulation of cathepsin K mRNA from cells cultured on plastic correlates with increased cathepsin K activation, overview ?
-
 ?
additional information Homo sapiens media from cells on plastic show higher CatK activation than cells on dentin, consistent with cellular expression of cathepsin K mRNA, 2fold upregulation of cathepsin K mRNA from cells cultured on plastic correlates with increased cathepsin K activation, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
 female BALB/c mice
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification trypsin cleaves at the cathepsin K recognition site activating cathepsin K Mus musculus
proteolytic modification trypsin cleaves at the cathepsin K recognition site activating cathepsin K Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
bone cathepsin K probe localizes adjacent to newly mineralizing bone in vivo Mus musculus
-
bone cathepsin K probe localizes adjacent to newly mineralizing bone in vivo Homo sapiens
-
additional information media from cells on plastic show higher CatK activation than cells on dentin, consistent with cellular expression of cathepsin K mRNA, 2fold upregulation of cathepsin K mRNA from cells cultured on plastic correlates with increased cathepsin K activation, overview Mus musculus
-
additional information media from cells on plastic show higher CatK activation than cells on dentin, consistent with cellular expression of cathepsin K mRNA, 2fold upregulation of cathepsin K mRNA from cells cultured on plastic correlates with increased cathepsin K activation, overview Homo sapiens
-
osteoclast
-
 Mus musculus
-
osteoclast
-
 Homo sapiens
-
RAW-264.7 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
collagen I + H2O
-
 Mus musculus ?
-
 ?
collagen I + H2O
-
 Homo sapiens ?
-
 ?
collagen I + H2O osteoclasts degrade bone matrix by demineralization followed by degradation of type I collagen through secretion of the cysteine protease, cathepsin K Mus musculus ?
-
 ?
collagen I + H2O osteoclasts degrade bone matrix by demineralization followed by degradation of type I collagen through secretion of the cysteine protease, cathepsin K Homo sapiens ?
-
 ?
additional information media from cells on plastic show higher CatK activation than cells on dentin, consistent with cellular expression of cathepsin K mRNA, 2fold upregulation of cathepsin K mRNA from cells cultured on plastic correlates with increased cathepsin K activation, overview Mus musculus ?
-
 ?
additional information media from cells on plastic show higher CatK activation than cells on dentin, consistent with cellular expression of cathepsin K mRNA, 2fold upregulation of cathepsin K mRNA from cells cultured on plastic correlates with increased cathepsin K activation, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
catK
-
 Mus musculus
catK
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
-
 Mus musculus
5.5
-
-
 Homo sapiens