Literature summary for 3.4.22.38 extracted from

Morley, A.D.; Kenny, P.W.; Burton, B.; Heald, R.A.; Macfaul, P.A.; Mullett, J.; Page, K.; Porres, S.S.; Ribeiro, L.R.; Smith, P.; Ward, S.; Wilkinson, T.J.
5-Aminopyrimidin-2-ylnitriles as cathepsin K inhibitors (2009), Bioorg. Med. Chem. Lett., 19, 1658-1661.

Search for more literature for 3.4.22.38

Application

Application	Comment	Organism
drug development	cathepsin K is seen as an attractive target for intervention in the treatment of both osteoporosis and osteoarthritis	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
4-(4-acetylpiperazin-1-yl)-5-amino-6-[(2-methylpropyl)amino]pyrimidine-2-carbonitrile	-	Homo sapiens
5-amino-4-(3-hydroxyazetidin-1-yl)-6-[(2-methylpropyl)amino]pyrimidine-2-carbonitrile	-	Homo sapiens
5-amino-4-(bicyclo[2.2.1]hept-2-ylamino)-6-morpholin-4-ylpyrimidine-2-carbonitrile	-	Homo sapiens
5-amino-4-(cyclohexylamino)-6-morpholin-4-ylpyrimidine-2-carbonitrile	-	Homo sapiens
5-amino-4-(cyclopentylamino)-6-morpholin-4-ylpyrimidine-2-carbonitrile	-	Homo sapiens
5-amino-4-morpholin-4-yl-6-(phenylamino)pyrimidine-2-carbonitrile	-	Homo sapiens
5-amino-4-morpholin-4-yl-6-(tetrahydrofuran-3-ylamino)pyrimidine-2-carbonitrile	-	Homo sapiens
5-amino-4-morpholin-4-yl-6-piperidin-1-ylpyrimidine-2-carbonitrile	-	Homo sapiens
5-amino-4-morpholin-4-yl-6-pyrrolidin-1-ylpyrimidine-2-carbonitrile	-	Homo sapiens
5-amino-4-[(1,1-dioxidotetrahydrothiophen-3-yl)amino]-6-[(2-methylpropyl)amino]pyrimidine-2-carbonitrile	-	Homo sapiens
5-amino-4-[(1-methylethyl)amino]-6-morpholin-4-ylpyrimidine-2-carbonitrile	-	Homo sapiens
5-amino-4-[(1-methylpropyl)amino]-6-morpholin-4-ylpyrimidine-2-carbonitrile	-	Homo sapiens
5-amino-4-[(2,2-dimethylpropyl)amino]-6-morpholin-4-ylpyrimidine-2-carbonitrile	-	Homo sapiens
5-amino-4-[(2-methoxyethyl)amino]-6-[(2-methylpropyl)amino]pyrimidine-2-carbonitrile	-	Homo sapiens
5-amino-4-[(2-methylpropyl)amino]-6-morpholin-4-ylpyrimidine-2-carbonitrile	-	Homo sapiens
5-amino-4-[(2-methylpropyl)amino]-6-piperazin-1-ylpyrimidine-2-carbonitrile	-	Homo sapiens
5-amino-4-[(2-methylpropyl)amino]-6-[(tetrazolidin-5-ylmethyl)amino]pyrimidine-2-carbonitrile	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
lysosome	-	Homo sapiens	5764	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000002	-	-	Homo sapiens	5-amino-4-(bicyclo[2.2.1]hept-2-ylamino)-6-morpholin-4-ylpyrimidine-2-carbonitrile
0.000006	-	-	Homo sapiens	5-amino-4-[(2-methylpropyl)amino]-6-piperazin-1-ylpyrimidine-2-carbonitrile
0.000009	-	-	Homo sapiens	4-(4-acetylpiperazin-1-yl)-5-amino-6-[(2-methylpropyl)amino]pyrimidine-2-carbonitrile
0.000013	-	-	Homo sapiens	5-amino-4-(cyclopentylamino)-6-morpholin-4-ylpyrimidine-2-carbonitrile
0.000014	-	-	Homo sapiens	5-amino-4-[(1,1-dioxidotetrahydrothiophen-3-yl)amino]-6-[(2-methylpropyl)amino]pyrimidine-2-carbonitrile
0.000017	-	-	Homo sapiens	5-amino-4-[(2,2-dimethylpropyl)amino]-6-morpholin-4-ylpyrimidine-2-carbonitrile
0.000018	-	-	Homo sapiens	5-amino-4-[(2-methylpropyl)amino]-6-morpholin-4-ylpyrimidine-2-carbonitrile
0.000022	-	-	Homo sapiens	5-amino-4-morpholin-4-yl-6-pyrrolidin-1-ylpyrimidine-2-carbonitrile
0.000023	-	-	Homo sapiens	5-amino-4-(cyclohexylamino)-6-morpholin-4-ylpyrimidine-2-carbonitrile
0.000024	-	-	Homo sapiens	5-amino-4-[(2-methoxyethyl)amino]-6-[(2-methylpropyl)amino]pyrimidine-2-carbonitrile
0.000032	-	-	Homo sapiens	5-amino-4-(3-hydroxyazetidin-1-yl)-6-[(2-methylpropyl)amino]pyrimidine-2-carbonitrile
0.00006	-	-	Homo sapiens	5-amino-4-morpholin-4-yl-6-piperidin-1-ylpyrimidine-2-carbonitrile
0.000062	-	-	Homo sapiens	5-amino-4-[(2-methylpropyl)amino]-6-[(tetrazolidin-5-ylmethyl)amino]pyrimidine-2-carbonitrile
0.00011	-	-	Homo sapiens	5-amino-4-morpholin-4-yl-6-(phenylamino)pyrimidine-2-carbonitrile
0.0003	-	-	Homo sapiens	5-amino-4-[(1-methylpropyl)amino]-6-morpholin-4-ylpyrimidine-2-carbonitrile
0.00034	-	-	Homo sapiens	5-amino-4-morpholin-4-yl-6-(tetrahydrofuran-3-ylamino)pyrimidine-2-carbonitrile
0.00056	-	-	Homo sapiens	5-amino-4-[(1-methylethyl)amino]-6-morpholin-4-ylpyrimidine-2-carbonitrile

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Release 2023.1 (January 2023)