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Literature summary for 3.4.22.38 extracted from

  • Dejica, V.M.; Mort, J.S.; Laverty, S.; Percival, M.D.; Antoniou, J.; Zukor, D.J.; Poole, A.R.
    Cleavage of type II collagen by cathepsin K in human osteoarthritic cartilage (2008), Am. J. Pathol., 173, 161-169.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
chondroitin 4-sulfate activates 2fold in 24 h Homo sapiens
chondroitin 6-sulfate activates 2.5fold in 24 h Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of procathepsin K in Pichia pastoris Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
L-873724 a cathepsin K inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
collagen II + H2O Homo sapiens cathepsin K is a cysteine protease of the papain family that cleaves triple-helical type II collagen, the major structural component of the extracellular matrix of articular cartilage ?
-
?
additional information Homo sapiens generation of a C-terminal neoepitope, C2K, in triple-helical type II collagen by the proteolytic action of cathepsin K, the optimal concentration of cathepsin K for generation of C2K neoepitope is 0.01 mM, effects of its presence in normal adult and osteoarthritic femoral condylar articular cartilage, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant procathepsin K from Pichia pastoris, processed to the mature form and purified Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
cartilage osteoarthritic and nonarthritic femoral condylar articular, and normal articular Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
collagen II + H2O cathepsin K is a cysteine protease of the papain family that cleaves triple-helical type II collagen, the major structural component of the extracellular matrix of articular cartilage Homo sapiens ?
-
?
collagen II + H2O human, the cleavage site is GEAGKPG_KAGERGPPG Homo sapiens ?
-
?
additional information generation of a C-terminal neoepitope, C2K, in triple-helical type II collagen by the proteolytic action of cathepsin K, the optimal concentration of cathepsin K for generation of C2K neoepitope is 0.01 mM, effects of its presence in normal adult and osteoarthritic femoral condylar articular cartilage, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
More cysteine protease of the papain family Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
5.5 7 collagen II cleaving activity Homo sapiens