Literature summary for 3.4.22.38 extracted from

Jaffer, F.A.; Kim, D.E.; Quinti, L.; Tung, C.H.; Aikawa, E.; Pande, A.N.; Kohler, R.H.; Shi, G.P.; Libby, P.; Weissleder, R.
Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensor (2007), Circulation, 115, 2292-2298.

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Application

Application	Comment	Organism
diagnostics	to assess better the biology of CatK activity in vivo, a novel near-infrared fluorescence (NIRF) probe for imaging of CatK is developed	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
atherosclerotic plaque	it is shown by fluorescence microscopy of plaque sections from using human carotid endarterectomy specimens that enzymatically active CatK (positive NIRF signal) localizes primarily in the vicinity of CatK-positive macrophages. Augmented NIRF signal (reflecting CatK activity) colocalizes with disrupted elastin fibers within the media underlying plaques	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the NIRF imaging agent consists of the CatK peptide substrate GHPGGPQGKC-NH2 linked to an activatable fluorogenic polymer. In vitro, CatK produces a 2- to 14fold activation of the agent	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
cathepsin K	-	Homo sapiens
catK	-	Homo sapiens

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Release 2023.1 (January 2023)