Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.38 extracted from

  • Guay, J.; Falgueyret, J.P.; Ducret, A.; Percival, M.D.; Mancini, J.A.
    Potency and selectivity of inhibition of cathepsin K, L and S by their respective propeptides (2000), Eur. J. Biochem., 267, 6311-6318.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of the propeptide in Escherichia coli as gluthatione S-transferase fusion protein Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
procathepsin K
-
Homo sapiens
procathepsin L
-
Homo sapiens
procathepsin S
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Z-Leu-Arg-4-methylcoumarin 7-amide + H2O
-
Homo sapiens Z-Leu-Arg + 7-amino-4-methylcoumarin
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00027
-
procathepsin L pH 5.5, room temperatur Homo sapiens
0.00055
-
procathepsin K pH 5.5, room temperatur Homo sapiens
0.0007
-
procathepsin S pH 5.5, room temperatur Homo sapiens