Literature summary for 3.4.22.38 extracted from

Kamiya, T.; Kobayashi, Y.; Kanaoka, K.; Nakashima, T.; Kato, Y.; Mizuno, A.; Sakai, H.
Fluorescence microscopic demonstration of cathepsin K activity a the major lysosomal cystein proteinase in osteoclasts (1998), J. Biochem., 123, 752-759.

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Inhibitors

Inhibitors	Comment	Organism	Structure
leupeptin	-	Mus musculus
leupeptin	-	Oryctolagus cuniculus
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane	-	Mus musculus
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane	i.e. E-64	Oryctolagus cuniculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Mus musculus	5737	-
cytoplasm	-	Oryctolagus cuniculus	5737	-
lysosome	-	Mus musculus	5764	-
lysosome	-	Oryctolagus cuniculus	5764	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-
Oryctolagus cuniculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	not in peritoneal macrophages	Mus musculus	-
additional information	not in peritoneal macrophages	Oryctolagus cuniculus	-
osteoclast	-	Mus musculus	-
osteoclast	-	Oryctolagus cuniculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Benzyloxycarbonyl-Leu-Arg 4-methoxy-2-naphthylamide + H2O	-	Mus musculus	Benzyloxycarbonyl-Leu-Arg + 4-methoxy-2-naphthylamine	-	?
Benzyloxycarbonyl-Leu-Arg 4-methoxy-2-naphthylamide + H2O	-	Oryctolagus cuniculus	Benzyloxycarbonyl-Leu-Arg + 4-methoxy-2-naphthylamine	-	?
Benzyloxycarbonyl-Leu-Arg 4-methylcoumarin 7-amide + H2O	-	Mus musculus	Benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin	-	?
Benzyloxycarbonyl-Leu-Arg 4-methylcoumarin 7-amide + H2O	-	Oryctolagus cuniculus	Benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin	-	?

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
5	6	-	Mus musculus
5	6	-	Oryctolagus cuniculus

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Release 2023.1 (January 2023)