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Literature summary for 3.4.22.38 extracted from

  • Aibe, K.; Yazawa, H.; Abe, K.; Teramura, K.; Kumegawa, M.; Kawashima, H.; Honda, K.
    Substrate specificity of recombinant osteoclast cathepsin K from rabbits (1996), Biol. Pharm. Bull., 19, 1026-1031.
    View publication on PubMed
Search for more literature for 3.4.22.38

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
leupeptin
-
 Oryctolagus cuniculus
additional information not inhibitory are phenylmethylsulfonylfluoride, disopropyfluorophosohate, soybean inhibitor, pepstatin A Oryctolagus cuniculus
N-Acetyl-Leu-Leu-methional
-
 Oryctolagus cuniculus
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane i.e. E-64 Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.013
-
 Benzyloxycarbonyl-Leu-Leu-Arg 4-methylcoumarin 7-amide tert-butyloxycarbonyl-Ala-Gly-Pro- Arg 4-methylcoumarin 7-amide Oryctolagus cuniculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37000
-
 unglycosylated procathepsin K, gel filtration Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Renatured (Commentary)

Renatured (Comment) Organism
otimal pH for renaturation is 9.8, renaturation in the range 7.5-12 Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
osteoclast
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Benzyloxycarbonyl-Gly-Pro-Arg 4-methylcoumarin 7-amide + H2O
-
 Oryctolagus cuniculus Benzyloxycarbonyl-Gly-Pro-Arg + 7-amino-4-methylcoumarin
-
 ?
Benzyloxycarbonyl-Leu-Leu-Arg 4-methylcoumarin 7-amide + H2O
-
 Oryctolagus cuniculus Benzyloxycarbonyl-Leu-Leu-Arg + 7-amino-4-methylcoumarin
-
 ?
Benzyloxycarbonyl-Phe-Arg 4-methylcoumarin 7-amide + H2O
-
 Oryctolagus cuniculus Benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
 ?
Benzyloxycarbonyl-Phe-Pro-Arg 4-methylcoumarin 7-amide + H2O
-
 Oryctolagus cuniculus Benzyloxycarbonyl-Phe-Pro-Arg + 7-amino-4-methylcoumarin
-
 ?
D-Phe-Phe-Arg 4-methylcoumarin 7-amide + H2O
-
 Oryctolagus cuniculus D-Phe-Phe-Arg + 7-amino-4-methylcoumarin
-
 ?
Pro-Phe-Arg 4-methylcoumarin 7-amide + H2O
-
 Oryctolagus cuniculus Pro-Phe-Arg + 7-amino-4-methylcoumarin
-
 ?
tert-Butyloxycarbonyl-Ala-Gly-Pro-Arg 4-methylcoumarin 7-amide + H2O
-
 Oryctolagus cuniculus tert-Butyloxycarbonyl-Ala-Gly-Pro-Arg + 7-amino-4-methylcoumarin
-
 ?
tert-Butyloxycarbonyl-Phe-Val-Arg 4-methylcoumarin 7-amide + H2O
-
 Oryctolagus cuniculus tert-Butyloxycarbonyl-Phe-Val-Arg + 7-amino-4-methylcoumarin
-
 ?
tert-Butyloxycarbonyl-Val-Pro-Arg 4-methylcoumarin 7-amide + H2O
-
 Oryctolagus cuniculus tert-Butyloxycarbonyl-Val-Pro-Arg + 7-amino-4-methylcoumarin
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
-
 Oryctolagus cuniculus

pH Range

pH Minimum pH Maximum Comment Organism
4 7.5
-
 Oryctolagus cuniculus