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Literature summary for 3.4.22.37 extracted from

  • van der Post, S.; Subramani, D.B.; Baeckstroem, M.; Johansson, M.E.; Vester-Christensen, M.B.; Mandel, U.; Bennett, E.P.; Clausen, H.; Dahlen, G.; Sroka, A.; Potempa, J.; Hansson, G.C.
    Site-specific O-glycosylation on the MUC2 mucin protein inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease (RgpB) (2013), J. Biol. Chem., 288, 14636-14646.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
E-64 reversible inhibitor Porphyromonas gingivalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Muc2 + H2O Porphyromonas gingivalis
-
?
-
?
Muc2 + H2O Porphyromonas gingivalis HG66
-
?
-
?

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
-
-
Porphyromonas gingivalis HG66
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
AWTPTPTPLSTPSIIRTTGLRPYPSSVLI + H2O
-
Porphyromonas gingivalis AWTPTPTPLSTPSIIR + TTGLRPYPSSVLI
-
?
AWTPTPTPLSTPSIIRTTGLRPYPSSVLI + H2O
-
Porphyromonas gingivalis HG66 AWTPTPTPLSTPSIIR + TTGLRPYPSSVLI
-
?
Muc2 + H2O
-
Porphyromonas gingivalis ?
-
?
Muc2 + H2O
-
Porphyromonas gingivalis HG66 ?
-
?

Synonyms

Synonyms Comment Organism
Arg-gingipain B
-
Porphyromonas gingivalis
Arginine-specific gingipain
-
Porphyromonas gingivalis
RgpB
-
Porphyromonas gingivalis

pH Range

pH Minimum pH Maximum Comment Organism
5 9.5 isoform RgpB has a broad pH optimum in the range of pH 9.5 (100% activity) down to pH 5.0 (50%) Porphyromonas gingivalis