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Literature summary for 3.4.22.37 extracted from

  • Ruggiero, S.; Cosgarea, R.; Potempa, J.; Potempa, B.; Eick, S.; Chiquet, M.
    Cleavage of extracellular matrix in periodontitis: gingipains differentially affect cell adhesion activities of fibronectin and tenascin-C (2013), Biochim. Biophys. Acta, 1832, 517-526.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Fibronectin + H2O Porphyromonas gingivalis the enzyme isoforms HRgpA and RgpB effectively destroy the cell-binding domain of fibronectin ?
-
 ?

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
arginine-Sepharose column chromatography, Mono Q column chromatography, and gel filtration Porphyromonas gingivalis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Fibronectin + H2O the enzyme isoforms HRgpA and RgpB effectively destroy the cell-binding domain of fibronectin Porphyromonas gingivalis ?
-
 ?

Synonyms

Synonyms Comment Organism
arginine-specific gingipain B
-
 Porphyromonas gingivalis
high molecular mass arginine-specific gingipain A
-
 Porphyromonas gingivalis
HRgpA isoform Porphyromonas gingivalis
RgpB isoform Porphyromonas gingivalis