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Literature summary for 3.4.22.37 extracted from

  • Uehara, A.; Imamura, T.; Potempa, J.; Travis, J.; Takada, H.
    Gingipains from Porphyromonas gingivalis synergistically induce the production of proinflammatory cytokines through protease-activated receptors with Toll-like receptor and NOD1/2 ligands in human monocytic cells (2008), Cell. Microbiol., 10, 1181-1189.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information gingipains stimulate interleukin-8 secretion from human THP-1 cells, which is completely inhibited by proteinase inhibitors of gingipain and is increased in the presence of pathogen-associated molecular patterns, PAMPs, overview. Synergistic effects of gingipains and, synthetic TLR or NOD ligands on secretion of proinflammatory cytokines in cultured human peripheral blood mononuclear cellshuman peripheral blood mononuclear cells Porphyromonas gingivalis

Inhibitors

Inhibitors Comment Organism Structure
additional information gingipains stimulate interleukin-8 secretion from human THP-1 cells, which is completely inhibited by proteinase inhibitors of gingipain and is increased in the presence of pathogen-associated molecular patterns, PAMPs, overview Porphyromonas gingivalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Porphyromonas gingivalis gingipains are cysteine proteinases and virulence factors of Porphyromonas gingivalis, the major causative bacterium of periodontal disease. Gingipains stimulate interleukin-8 secretion from human THP-1 cells, which is completely inhibited by proteinase inhibitors of gingipain and is increased in the presence of pathogen-associated molecular patterns, PAMPs, overview ?
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Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information gingipains are cysteine proteinases and virulence factors of Porphyromonas gingivalis, the major causative bacterium of periodontal disease. Gingipains stimulate interleukin-8 secretion from human THP-1 cells, which is completely inhibited by proteinase inhibitors of gingipain and is increased in the presence of pathogen-associated molecular patterns, PAMPs, overview Porphyromonas gingivalis ?
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Synonyms

Synonyms Comment Organism
gingipain
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Porphyromonas gingivalis
HRgpA
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Porphyromonas gingivalis
RgpB
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Porphyromonas gingivalis