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Literature summary for 3.4.22.37 extracted from
- Selective proteolysis of apolipoprotein B-100 by Arg-gingipain mediates atherosclerosis progression accelerated by bacterial exposure (2006), J. Biochem., 140, 713-723.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| KYT-1 | specific inhibitor | Porphyromonas gingivalis |  |
| KYT-36 | - |
Porphyromonas gingivalis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| apoB-100 protein + H2O | Porphyromonas gingivalis | apoB-100 degradation induces LDL-modification and contributes to the onset of atherosclerosis | ? | - |
? | |
| additional information | Porphyromonas gingivalis | implicated in a wide range of both pathological and physiological processes of Porphyromonas gingivalis, including destruction of periodontal tissue, disruption of host defense mechanisms, processing of bacterial cell surface and secretory proteins, and acquisition of heme and amino acids, involved in atherosclerotic processes | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Porphyromonas gingivalis | - |
strains ATCC 33277 (wild type), the Rgp/Kgp-null (rgpA rgpB kgpdeficient) triple-mutant KDP136, the Kgp-null (kgp) mutant (KDP129),and an Rgp-null (rgpA rgpBdeficient) double-mutant (KDP133) | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| apoB-100 protein + H2O | apoB-100 degradation induces LDL-modification and contributes to the onset of atherosclerosis | Porphyromonas gingivalis | ? | - |
? | |
| additional information | implicated in a wide range of both pathological and physiological processes of Porphyromonas gingivalis, including destruction of periodontal tissue, disruption of host defense mechanisms, processing of bacterial cell surface and secretory proteins, and acquisition of heme and amino acids, involved in atherosclerotic processes | Porphyromonas gingivalis | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Arg-gingipain | cysteine proteinase | Porphyromonas gingivalis |
| RGP | - |
Porphyromonas gingivalis |
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