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Literature summary for 3.4.22.37 extracted from

  • Baba, A.; Abe, N.; Kadowaki, T.; Nakanishi, H.; Ohishi, M.; Asao, T.; Yamamoto, K.
    Arg-gingipain is responsible for the degradation of cell adhesion molecules of human gingival fibroblasts and their death induced by Porphyromonas gingivalis (2001), Biol. Chem., 382, 817-824.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Collagen type I fibronectin and type I collagen addition inhibited the disruptive activity of the enzyme in human fibroblasts Porphyromonas gingivalis
fibronectin fibronectin and type I collagen addition inhibited the disruptive activity of the enzyme in human fibroblasts Porphyromonas gingivalis
leupeptin
-
Porphyromonas gingivalis

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Porphyromonas gingivalis
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
integrin subunit alpha2 + H2O Porphyromonas gingivalis
-
?
-
?
integrin subunit alpha2 + H2O Porphyromonas gingivalis ATCC 33277
-
?
-
?
integrin subunit beta1 + H2O Porphyromonas gingivalis
-
?
-
?
integrin subunit beta1 + H2O Porphyromonas gingivalis ATCC 33277
-
?
-
?
integrin subunit beta3 + H2O Porphyromonas gingivalis
-
?
-
?
integrin subunit beta3 + H2O Porphyromonas gingivalis ATCC 33277
-
?
-
?
additional information Porphyromonas gingivalis enzyme disrupts interaction between fibronectin and integrin in human fibroblasts, leading to cell death of detached fibroblasts, which contributes to the tissue damage in periodontal disease caused by Porphyromonas gingivalis ?
-
?
additional information Porphyromonas gingivalis ATCC 33277 enzyme disrupts interaction between fibronectin and integrin in human fibroblasts, leading to cell death of detached fibroblasts, which contributes to the tissue damage in periodontal disease caused by Porphyromonas gingivalis ?
-
?
profibronectin + H2O Porphyromonas gingivalis
-
fibronectin + ?
-
?
profibronectin + H2O Porphyromonas gingivalis ATCC 33277
-
fibronectin + ?
-
?

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
strain ATCC33277
-
Porphyromonas gingivalis ATCC 33277
-
strain ATCC33277
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
integrin subunit alpha2 + H2O
-
Porphyromonas gingivalis ?
-
?
integrin subunit alpha2 + H2O
-
Porphyromonas gingivalis ATCC 33277 ?
-
?
integrin subunit beta1 + H2O
-
Porphyromonas gingivalis ?
-
?
integrin subunit beta1 + H2O
-
Porphyromonas gingivalis ATCC 33277 ?
-
?
integrin subunit beta3 + H2O
-
Porphyromonas gingivalis ?
-
?
integrin subunit beta3 + H2O
-
Porphyromonas gingivalis ATCC 33277 ?
-
?
additional information enzyme disrupts interaction between fibronectin and integrin in human fibroblasts, leading to cell death of detached fibroblasts, which contributes to the tissue damage in periodontal disease caused by Porphyromonas gingivalis Porphyromonas gingivalis ?
-
?
additional information enzyme disrupts interaction between fibronectin and integrin in human fibroblasts, leading to cell death of detached fibroblasts, which contributes to the tissue damage in periodontal disease caused by Porphyromonas gingivalis Porphyromonas gingivalis ATCC 33277 ?
-
?
profibronectin + H2O
-
Porphyromonas gingivalis fibronectin + ?
-
?
profibronectin + H2O
-
Porphyromonas gingivalis ATCC 33277 fibronectin + ?
-
?

Synonyms

Synonyms Comment Organism
Arg-gingipain
-
Porphyromonas gingivalis
Arginine-specific cysteine protease
-
Porphyromonas gingivalis
RGP
-
Porphyromonas gingivalis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Porphyromonas gingivalis