Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.36 extracted from

  • Bulau, A.M.; Nold, M.F.; Li, S.; Nold-Petry, C.A.; Fink, M.; Mansell, A.; Schwerd, T.; Hong, J.; Rubartelli, A.; Dinarello, C.A.; Bufler, P.
    Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses (2014), Proc. Natl. Acad. Sci. USA, 111, 2650-2655.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.36

Inhibitors

Inhibitors Comment Organism Structure
N-benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethylketone
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-interleukin-18 + H2O Mus musculus
-
 interleukin-18 propeptide
-
 ?
pro-interleukin-1beta + H2O Mus musculus
-
 interleukin-1beta propeptide
-
 ?
pro-interleukin-37 + H2O Mus musculus caspase-1 processing at position D20 activates interleukin-37 interleukin-37 propeptide
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow-derived macrophage
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-interleukin-18 + H2O
-
 Mus musculus interleukin-18 propeptide
-
 ?
pro-interleukin-1beta + H2O
-
 Mus musculus interleukin-1beta propeptide
-
 ?
pro-interleukin-37 + H2O caspase-1 processing at position D20 activates interleukin-37 Mus musculus interleukin-37 propeptide
-
 ?

General Information

General Information Comment Organism
metabolism caspase-1 is required for nuclear translocation of intracellular interleukin-37 and for secretion of mature interleukin-37 Mus musculus