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Literature summary for 3.4.22.36 extracted from

  • Datta, D.; McClendon, C.L.; Jacobson, M.P.; Wells, J.A.
    Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3 (2013), J. Biol. Chem., 288, 9971-9981.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information substrate binding increases the dimerization affinity and activity of caspase-1 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) Star cells as insoluble inclusion bodies Homo sapiens

Protein Variants

Protein Variants Comment Organism
C285A active site null mutant Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone irreversible active site inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-interleukin-1beta + H2O Homo sapiens
-
interleukin-1beta propeptide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P29466
-
-

Purification (Commentary)

Purification (Comment) Organism
HiTrap Ni-NTA column chromatography and Superdex 200 gel filtration Homo sapiens

Renatured (Commentary)

Renatured (Comment) Organism
50 mM HEPES (pH 8.0), 100 mM NaCl, 10% (w/v) sucrose, 1 M nondetergent sulfobetaine 201, and 10 mM dithiothreitol Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-WEHD-7-amido-4-trifluoromethylcoumarin + H2O
-
Homo sapiens N-acetyl-WEHD + 7-amino-4-trifluoromethylcoumarin
-
?
pro-interleukin-1beta + H2O
-
Homo sapiens interleukin-1beta propeptide
-
?

Subunits

Subunits Comment Organism
monomer or dimer mature caspase-1 exists predominantly as a monomer under physiological concentration that undergoes dimerization in the presence of substrate Homo sapiens