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Literature summary for 3.4.22.36 extracted from

  • Narayanan, K.B.; Park, H.H.
    Purification and analysis of the interactions of caspase-1 and ASC for assembly of the inflammasome (2015), Appl. Biochem. Biotechnol., 175, 2883-2894.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
VX-765
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-interleukin-1beta + H2O Homo sapiens
-
interleukin-1beta propeptide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-interleukin-1beta + H2O
-
Homo sapiens interleukin-1beta propeptide
-
?

General Information

General Information Comment Organism
physiological function caspase-1 is one of the main components of the NALP3 inflammasome Homo sapiens