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Literature summary for 3.4.22.36 extracted from
- Coordinated host responses during pyroptosis: caspase-1-dependent lysosome exocytosis and inflammatory cytokine maturation (2011), J. Immunol., 187, 2748-2754.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| macrophage | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| caspase-1 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | lysosome exocytosis is a conserved caspase-1-dependent feature of pyroptosis. Caspase-1 activation leads to increased membrane permeability and an influx of calcium, which results in fusion of lysosomes with the cell surface and release of lysosomal contents. Secretion of processed IL-1beta and IL-18 in macrophages undergoing pyroptosis occurs independently of lysosome exocytosis. Multiple stimuli, acting through a diverse set of NLR proteins, lead to two conserved caspase-1-dependent secretion events: the release of processed inflammatory cytokines and lysosome-mediated release of antimicrobial host factors and degraded microbial products | Mus musculus |
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Release 2023.1 (January 2023)
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