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Literature summary for 3.4.22.36 extracted from

  • Morishige, T.; Yoshioka, Y.; Tanabe, A.; Yao, X.; Tsunoda, S.; Tsutsumi, Y.; Mukai, Y.; Okada, N.; Nakagawa, S.
    Titanium dioxide induces different levels of IL-1beta production dependent on its particle characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin B (2010), Biochem. Biophys. Res. Commun., 392, 160-165.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information the inflammasome activator ATP can induce the production of reactive oxygen species, which are important for caspase-1 activation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
carbobenzoxy-L-valyl-L-alanyl-L-aspartyl-[O-methyl]-fluoromethylketone caspase-1-specific inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-interleukin-1beta + H2O Homo sapiens
-
 mature interleukin-1beta + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
THP-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-interleukin-1beta + H2O
-
 Homo sapiens mature interleukin-1beta + ?
-
 ?