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Literature summary for 3.4.22.36 extracted from
- Ritonavir and disulfiram have potential to inhibit caspase-1 mediated inflammation and reduce neurological sequelae after minor blast exposure (2009), Med. Hypotheses, 72, 150-152.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | caspase-1 is activated and central to neuronal damage in disparate brain injuring events: neonatal exposure to high O2 levels, cold injury, ischemic injury, excitotoxic injury, acceleration injury, the neurotoxic recreational drug methylenedioxymethamphetamine, MDMA, and others | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Disulfiram | inhibits the enzyme | Homo sapiens |  |
| Disulfiram | inhibits the enzyme | Mus musculus | |
| Disulfiram | inhibits the enzyme | Rattus norvegicus | |
| additional information | caspase inhibition enhances neuronal survivability or protection | Homo sapiens | |
| additional information | caspase inhibition enhances neuronal survivability or protection | Mus musculus | |
| additional information | caspase inhibition enhances neuronal survivability or protection | Rattus norvegicus | |
| ritonavir | blocks caspase-1 activation and inhibits the enzyme | Homo sapiens | |
| ritonavir | blocks caspase-1 activation and inhibits the enzyme | Mus musculus | |
| ritonavir | blocks caspase-1 activation and inhibits the enzyme | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 45000 | - |
x * 45000, pro-caspase-1, SDS-PAGE | Mus musculus |
| 45000 | - |
x * 45000, pro-caspase-1, SDS-PAGE | Homo sapiens |
| 45000 | - |
x * 45000, pro-caspase-1, SDS-PAGE | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | caspase-1 is crucial in mediating neuronal apoptosis and inflammation after mechanical trauma, upregulated caspase-1 in the hours after trauma precedes neuron loss and mRNA and protein levels of interleukin-1beta and interleukin-18 are also increased | ? | - |
? | |
| additional information | Rattus norvegicus | caspase-1 is crucial in mediating neuronal apoptosis and inflammation after mechanical trauma, upregulated caspase-1 in the hours after trauma precedes neuron loss and mRNA and protein levels of interleukin-1beta and interleukin-18 are also increased | ? | - |
? | |
| additional information | Homo sapiens | caspase-1 is crucial in mediating neuronal apoptosis and inflammation after mechanical trauma, upregulated caspase-1 in the hours after trauma precedes neuron loss and mRNA and protein levels of interleukin-1beta and interleukin-18 are also increased. Caspase-1 is activated and central to neuronal damage in disparate brain injuring events: neonatal exposure to high O2 levels, cold injury, ischemic injury, excitotoxic injury, acceleration injury, the neurotoxic recreational drug methylenedioxymethamphetamine, MDMA, and others | ? | - |
? | |
| pro-interleukin-18 + H2O | Mus musculus | - |
interleukin-18 + ? | - |
? | |
| pro-interleukin-18 + H2O | Homo sapiens | - |
interleukin-18 + ? | - |
? | |
| pro-interleukin-18 + H2O | Rattus norvegicus | - |
interleukin-18 + ? | - |
? | |
| pro-interleukin-1beta + H2O | Mus musculus | - |
interleukin-1beta + ? | - |
? | |
| pro-interleukin-1beta + H2O | Homo sapiens | - |
interleukin-1beta + ? | - |
? | |
| pro-interleukin-1beta + H2O | Rattus norvegicus | - |
interleukin-1beta + ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | pro-caspase-1 is a 45 kDa molecule that autocatalyzes to form active caspase-1 | Rattus norvegicus |
| proteolytic modification | pro-caspase-1 is a 45 kDa molecule that autocatalyzes to form active caspase-1, it is also activated by caspase-11 | Mus musculus |
| proteolytic modification | pro-caspase-1 is a 45 kDa molecule that autocatalyzes to form active caspase-1, it is also activated by caspase-5 | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| brain | - |
Homo sapiens | - |
| brain | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | caspase-1 is crucial in mediating neuronal apoptosis and inflammation after mechanical trauma, upregulated caspase-1 in the hours after trauma precedes neuron loss and mRNA and protein levels of interleukin-1beta and interleukin-18 are also increased | Mus musculus | ? | - |
? | |
| additional information | caspase-1 is crucial in mediating neuronal apoptosis and inflammation after mechanical trauma, upregulated caspase-1 in the hours after trauma precedes neuron loss and mRNA and protein levels of interleukin-1beta and interleukin-18 are also increased | Rattus norvegicus | ? | - |
? | |
| additional information | caspase-1 is crucial in mediating neuronal apoptosis and inflammation after mechanical trauma, upregulated caspase-1 in the hours after trauma precedes neuron loss and mRNA and protein levels of interleukin-1beta and interleukin-18 are also increased. Caspase-1 is activated and central to neuronal damage in disparate brain injuring events: neonatal exposure to high O2 levels, cold injury, ischemic injury, excitotoxic injury, acceleration injury, the neurotoxic recreational drug methylenedioxymethamphetamine, MDMA, and others | Homo sapiens | ? | - |
? | |
| pro-interleukin-18 + H2O | - |
Mus musculus | interleukin-18 + ? | - |
? | |
| pro-interleukin-18 + H2O | - |
Homo sapiens | interleukin-18 + ? | - |
? | |
| pro-interleukin-18 + H2O | - |
Rattus norvegicus | interleukin-18 + ? | - |
? | |
| pro-interleukin-18 + H2O | active caspase-1 converts inactive pro-interleukin-18 to active interleukin-18 | Mus musculus | interleukin-18 + ? | - |
? | |
| pro-interleukin-18 + H2O | active caspase-1 converts inactive pro-interleukin-18 to active interleukin-18 | Homo sapiens | interleukin-18 + ? | - |
? | |
| pro-interleukin-18 + H2O | active caspase-1 converts inactive pro-interleukin-18 to active interleukin-18 | Rattus norvegicus | interleukin-18 + ? | - |
? | |
| pro-interleukin-1beta + H2O | - |
Mus musculus | interleukin-1beta + ? | - |
? | |
| pro-interleukin-1beta + H2O | - |
Homo sapiens | interleukin-1beta + ? | - |
? | |
| pro-interleukin-1beta + H2O | - |
Rattus norvegicus | interleukin-1beta + ? | - |
? | |
| pro-interleukin-1beta + H2O | active caspase-1 converts inactive 31 kDa pro-interleukin-1beta to 18 kDa active interleukin-1beta | Mus musculus | interleukin-1beta + ? | - |
? | |
| pro-interleukin-1beta + H2O | active caspase-1 converts inactive 31 kDa pro-interleukin-1beta to 18 kDa active interleukin-1beta | Homo sapiens | interleukin-1beta + ? | - |
? | |
| pro-interleukin-1beta + H2O | active caspase-1 converts inactive 31 kDa pro-interleukin-1beta to 18 kDa active interleukin-1beta | Rattus norvegicus | interleukin-1beta + ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 45000, pro-caspase-1, SDS-PAGE | Mus musculus |
| ? | x * 45000, pro-caspase-1, SDS-PAGE | Homo sapiens |
| ? | x * 45000, pro-caspase-1, SDS-PAGE | Rattus norvegicus |
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