Activating Compound | Comment | Organism | Structure |
---|---|---|---|
adapter protein Asc | is important for caspase-1 activation during Legionella pneumophila infection, mechanism, overview. Activation of caspase-1 through Asc does not require the flagellin-sensing pathway involving the host nucleotide-binding domain and leucine-rich repeat-containing protein Ipaf, NLRC4. Asc-dependent caspase-1 activation is inhibited by high extracellular potassium levels | Mus musculus | |
Ipaf | i.e. host nucleotide-binding domain and leucine-rich repeatcontaining protein Ipaf or NLRC4, Ipaf-dependent activation is unaffected by potassium treatment | Mus musculus | |
additional information | activation of caspase-1 in macrophages occurs independently of Nalp3 and proteasome activity | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
K+ | high extracellular K+ levels inhibit Asc-dependent caspase-1 activation, whereas Ipaf-dependent activation was unaffected by potassium treatment | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | caspase-1 activation is a key feature of the innate immune response of macrophages elicited by pathogens and a variety of toxins | ? | - |
? | |
additional information | Mus musculus C57BL/6 | caspase-1 activation is a key feature of the innate immune response of macrophages elicited by pathogens and a variety of toxins | ? | - |
? | |
pro-interleukin-18 + H2O | Mus musculus | - |
mature interleukin-18 | - |
? | |
pro-interleukin-18 + H2O | Mus musculus C57BL/6 | - |
mature interleukin-18 | - |
? | |
pro-interleukin-1beta + H2O | Mus musculus | - |
mature interleukin-1beta | - |
? | |
pro-interleukin-1beta + H2O | Mus musculus C57BL/6 | - |
mature interleukin-1beta | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6 mice | - |
Mus musculus C57BL/6 | - |
C57BL/6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | - |
Mus musculus | - |
macrophage | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | caspase-1 activation is a key feature of the innate immune response of macrophages elicited by pathogens and a variety of toxins | Mus musculus | ? | - |
? | |
additional information | caspase-1 activation is a key feature of the innate immune response of macrophages elicited by pathogens and a variety of toxins | Mus musculus C57BL/6 | ? | - |
? | |
pro-interleukin-18 + H2O | - |
Mus musculus | mature interleukin-18 | - |
? | |
pro-interleukin-18 + H2O | - |
Mus musculus C57BL/6 | mature interleukin-18 | - |
? | |
pro-interleukin-1beta + H2O | - |
Mus musculus | mature interleukin-1beta | - |
? | |
pro-interleukin-1beta + H2O | - |
Mus musculus C57BL/6 | mature interleukin-1beta | - |
? |