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Literature summary for 3.4.22.36 extracted from

  • Shahripour, A.B.; Plummer, M.S.; Lunney, E.A.; Albrecht, H.P.; Hays, S.J.; Kostlan, C.R.; Sawyer, T.K.; Walker, N.P.; Brady, K.D.; Allen, H.J.; Talanian, R.V.; Wong, W.W.; Humblet, C.
    Structure-based design of nonpeptide inhibitors of interleukin-1beta converting enzyme (ICE, caspase-1) (2002), Bioorg. Med. Chem., 10, 31-40.
    View publication on PubMed
Search for more literature for 3.4.22.36

Inhibitors

Inhibitors Comment Organism Structure
(S)-2-(4'-methyl-biphenyl-2-sulfonylamino)-4-oxo-butyric acid
-
 Homo sapiens
(S)-3-(2'-methyl-biphenyl-2-sulfonylamino)-4-oxo-butyric acid
-
 Homo sapiens
(S)-3-(2-naphthalen-1-yl-benzenesulfonylamino)-4-oxo-butyric acid
-
 Homo sapiens
(S)-3-(3'-acetylamino-biphenyl-2-sulfonylamino)-4-oxo-butyric acid
-
 Homo sapiens
(S)-3-(3'-methyl-biphenyl-2-sulfonylamino)-4-oxo-butyric acid
-
 Homo sapiens
(S)-3-(6-methyl-biphenyl-2-sulfonylamino)-4-oxo-butyric acid
-
 Homo sapiens
(S)-3-(biphenyl-2-sulfonylamino)-4-oxobutyric acid
-
 Homo sapiens
(S)-3-benzenesulfonylamino-4-oxo-5-(3-phenyl-propylsulfanyl)-pentanoic acid
-
 Homo sapiens
(S)-3-benzenesulfonylamino-4-oxo-9-phenyl-nonanoic acid
-
 Homo sapiens
(S)-3-benzyloxycarbonylamino-4-oxo-5-(3-phenyl-propylsulfanyl)-pentanoic acid
-
 Homo sapiens
(S)-3-benzyloxycarbonylamino-4-oxo-9-phenyl-nonanoic acid
-
 Homo sapiens
(S)-3-benzynesulfonylamino-4-oxo-butyric acid
-
 Homo sapiens
acetyl-Tyr-Val-Ala-Asp-CO-(CH2)5-Ph
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000011
-
 acetyl-Tyr-Val-Ala-Asp-CO-(CH2)5-Ph pH 7.5 Homo sapiens
0.0016
-
 (S)-3-(biphenyl-2-sulfonylamino)-4-oxobutyric acid
-
 Homo sapiens
0.0019
-
 (S)-3-(6-methyl-biphenyl-2-sulfonylamino)-4-oxo-butyric acid
-
 Homo sapiens
0.0023
-
 (S)-3-(3'-acetylamino-biphenyl-2-sulfonylamino)-4-oxo-butyric acid
-
 Homo sapiens
0.0031
-
 (S)-3-(3'-methyl-biphenyl-2-sulfonylamino)-4-oxo-butyric acid
-
 Homo sapiens
0.0068
-
 (S)-3-(2'-methyl-biphenyl-2-sulfonylamino)-4-oxo-butyric acid
-
 Homo sapiens
0.0069
-
 (S)-3-(2-naphthalen-1-yl-benzenesulfonylamino)-4-oxo-butyric acid
-
 Homo sapiens
0.0072
-
 (S)-2-(4'-methyl-biphenyl-2-sulfonylamino)-4-oxo-butyric acid
-
 Homo sapiens
0.0094
-
 (S)-3-benzynesulfonylamino-4-oxo-butyric acid
-
 Homo sapiens
0.024
-
 (S)-3-benzenesulfonylamino-4-oxo-5-(3-phenyl-propylsulfanyl)-pentanoic acid
-
 Homo sapiens
0.024
-
 (S)-3-benzenesulfonylamino-4-oxo-9-phenyl-nonanoic acid
-
 Homo sapiens
0.025
-
 (S)-3-benzyloxycarbonylamino-4-oxo-5-(3-phenyl-propylsulfanyl)-pentanoic acid
-
 Homo sapiens
0.119
-
 (S)-3-benzyloxycarbonylamino-4-oxo-9-phenyl-nonanoic acid
-
 Homo sapiens