Literature summary for 3.4.22.36 extracted from

Margolin, N.; Raybuck, S.A.; Wilson, K.P.; Chen, W.; Fox, T.; Gu, Y.; Livingston, D.J.
Substrate and inhibitor specificity of interleukin-1beta-converting enzyme and related caspases (1997), J. Biol. Chem., 272, 7223-7228.

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Inhibitors

Inhibitors	Comment	Organism	Structure
acetyl-DEVD-aldehyde	-	Homo sapiens
acetyl-YVAD-aldehyde	-	Homo sapiens
Glu-Val-Asp-aldehyde	-	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.000004	-	pro-interleukin-1beta	pH 7.5	Homo sapiens
0.0000115	-	acetyl-YVAD-7-amido-4-methylcoumarin	pH 7.5	Homo sapiens
0.0000134	-	4-[[4'-(dimethylamino)phenyl]azo]-benzoic acid-YVADAPV-5-[(2'-aminoethyl)-amino]naphthalenesulfonic acid	pH 7.5	Homo sapiens
0.0000215	-	succinyl-YVAD-4-nitroanilide	pH 7.5	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P29466	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-[[4'-(dimethylamino)phenyl]azo]-benzoic acid-YVADAPV-5-[(2'-aminoethyl)-amino]naphthalenesulfonic acid + H2O	-	Homo sapiens	4-[[4'-(dimethylamino)phenyl]azo]-benzoic acid-YVADAPV + 5-[(2-aminoethyl)-amino]naphthalenesulfonic acid	-	?
acetyl-YVAD-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	acetyl-YVAD + 7-amino-4-methylcoumarin	-	?
poly(ADP-ribose)polymerase + H2O	-	Homo sapiens	?	-	?
pre-interleukin-1beta + H2O	cleavage to the mature interleukin-1beta	Homo sapiens	17000 Da fragment + 28000 Da fragment	-	?
succinyl-YVAD-4-nitroanilide + H2O	-	Homo sapiens	succinyl-YVAD + 4-nitroaniline	-	?

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.41	-	4-[[4'-(dimethylamino)phenyl]azo]-benzoic acid-YVADAPV-5-[(2'-aminoethyl)-amino]naphthalenesulfonic acid	pH 7.5	Homo sapiens
1	-	acetyl-YVAD-7-amido-4-methylcoumarin	pH 7.5	Homo sapiens
1.2	-	pro-interleukin-1beta	pH 7.5	Homo sapiens
1.6	-	succinyl-YVAD-4-nitroanilide	pH 7.5	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000006	-	acetyl-YVAD-aldehyde	pH 7.5	Homo sapiens
0.000015	-	acetyl-DEVD-aldehyde	pH 7.5	Homo sapiens
0.00036	-	Glu-Val-Asp-aldehyde	pH 7.5	Homo sapiens

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Release 2023.1 (January 2023)