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Literature summary for 3.4.22.35 extracted from

  • Hou, Y.; Mortimer, L.; Chadee, K.
    Entamoeba histolytica cysteine proteinase 5 binds integrin on colonic cells and stimulates NFkappaB-mediated pro-inflammatory responses (2010), J. Biol. Chem., 285, 35497-35504.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Muc2 + H2O Entamoeba histolytica
-
 ?
-
 ?
Muc2 + H2O Entamoeba histolytica HM1:IMSS
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Entamoeba histolytica
-
-
-
Entamoeba histolytica HM1:IMSS
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Muc2 + H2O
-
 Entamoeba histolytica ?
-
 ?
Muc2 + H2O
-
 Entamoeba histolytica HM1:IMSS ?
-
 ?

Synonyms

Synonyms Comment Organism
cysteine proteinase 5
-
 Entamoeba histolytica
PCP5 isoform Entamoeba histolytica

Expression

Organism Comment Expression
Entamoeba histolytica when Entamoeba histolytica is grown in the presence of E-64, PCP5 levels are significantly increased up

General Information

General Information Comment Organism
physiological function cysteine proteinase 5 is a major virulent factor that binds integrin on colonic cells and stimulates nuclear factor kappaB-mediated pro-inflammatory responses. Cysteine proteinase 5 is the critical proteinase involved in activating nuclear factor kappaB, phosphorylating Akt and inducing the ubiquitination of nuclear factor-kappaB essential modulator Entamoeba histolytica