Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Muc2 + H2O | Entamoeba histolytica | - |
? | - |
? | |
Muc2 + H2O | Entamoeba histolytica HM1:IMSS | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Entamoeba histolytica | - |
- |
- |
Entamoeba histolytica HM1:IMSS | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Muc2 + H2O | - |
Entamoeba histolytica | ? | - |
? | |
Muc2 + H2O | - |
Entamoeba histolytica HM1:IMSS | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cysteine proteinase 5 | - |
Entamoeba histolytica |
PCP5 | isoform | Entamoeba histolytica |
Organism | Comment | Expression |
---|---|---|
Entamoeba histolytica | when Entamoeba histolytica is grown in the presence of E-64, PCP5 levels are significantly increased | up |
General Information | Comment | Organism |
---|---|---|
physiological function | cysteine proteinase 5 is a major virulent factor that binds integrin on colonic cells and stimulates nuclear factor kappaB-mediated pro-inflammatory responses. Cysteine proteinase 5 is the critical proteinase involved in activating nuclear factor kappaB, phosphorylating Akt and inducing the ubiquitination of nuclear factor-kappaB essential modulator | Entamoeba histolytica |