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Literature summary for 3.4.22.35 extracted from

  • Tillack, M.; Nowak, N.; Lotter, H.; Bracha, R.; Mirelman, D.; Tannich, E.; Bruchhaus, I.
    Increased expression of the major cysteine proteinases by stable episomal transfection underlines the important role of EhCP5 for the pathogenicity of Entamoeba histolytica (2006), Mol. Biochem. Parasitol., 149, 58-64.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
genes ehcp1, ehcp2, and ehcp5, stable episomal transfection, overexpression of EhCP5 highly increases activity of EhCP1, EhCP2, and EhCP5 in recombinant amoeba and cytopathic activity, while overexpression of EhCP1 or 2 enhances only the single activity and moderately enhances cytopathic activity, overview Entamoeba histolytica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Entamoeba histolytica the enzyme shows cytopathic effects and destroys cell monolayers ?
-
?

Organism

Organism UniProt Comment Textmining
Entamoeba histolytica
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isolate HM-1:IMSS, genes ehcp1, ehcp2, and ehcp5
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Source Tissue

Source Tissue Comment Organism Textmining
trophozoite
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Entamoeba histolytica
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
cytopathic activity of wild-type and recombinant amoebae Entamoeba histolytica

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme shows cytopathic effects and destroys cell monolayers Entamoeba histolytica ?
-
?
Z-Arg-Arg-4-nitroanilide + H2O
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Entamoeba histolytica Z-Arg-Arg + 4-nitroaniline
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?

Synonyms

Synonyms Comment Organism
EhCP1
-
Entamoeba histolytica
EhCP2
-
Entamoeba histolytica
EhCP5
-
Entamoeba histolytica