Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | mRNAs is up-regulated in the endometrium during the luteal phase of the oestrous cycle and during early pregnancy | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha-2-Macroglobulin | proteinase inhibitor, may be a candidate for the binding of legumain as it is an agent for the removal of endopeptidases from extracellular fluids | Bos taurus | |
cystatin E | high affinity inhibitor of legumain | Bos taurus | |
cystatin M | high affinity inhibitor of legumain | Bos taurus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
35000 | - |
mature form in uterine luminal fluid, determined by SDS-PAGE | Bos taurus |
49000 | - |
active form, determined by SDS-PAGE | Bos taurus |
56000 | - |
proform, determined by SDS-PAGE | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Bos taurus | enzyme is a protease which specifically cleaves on the carboxyl side of asparagine residues | ? | - |
? | |
additional information | Bos taurus | the function of legumain in the endometrium during early placentation may be through its role as an activator of protease zymogens such as progelatinase A | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | Q95M12 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
uterine endometrium | - |
Bos taurus | - |
uterine luminal fluid | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme is a protease which specifically cleaves on the carboxyl side of asparagine residues | Bos taurus | ? | - |
? | |
additional information | the function of legumain in the endometrium during early placentation may be through its role as an activator of protease zymogens such as progelatinase A | Bos taurus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
legumain | - |
Bos taurus |