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Literature summary for 3.4.22.29 extracted from

  • Deng, H.; Fung, G.; Qiu, Y.; Wang, C.; Zhang, J.; Jin, Z.G.; Luo, H.
    Cleavage of Grb2-associated binding protein 2 by viral proteinase 2A during coxsackievirus infection (2017), Front. Cell. Infect. Microbiol., 7, 85 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.29

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Grb2-associated binding protein 1 + H2O Coxsackievirus B3 GAB1 is cleaved during CV-B3 infection by viral proteinase 2A ?
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 ?
Grb2-associated binding protein 2 + H2O Coxsackievirus B3 GAB2 is cleaved at G238 during CV-B3 infection by viral proteinase 2A, generating two cleaved fragments of GAB2-N1-237 and GAB2-C238-676 GAB2-N1-237 + GAB2-C238-676
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 ?
additional information Coxsackievirus B3 in vivo assays by expression of GAB2 proteins in virus-infected HeLa cells ?
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 ?

Organism

Organism UniProt Comment Textmining
Coxsackievirus B3
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 CV-B3
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Source Tissue

Source Tissue Comment Organism Textmining
additional information the virus is propagated in HeLa cells Coxsackievirus B3
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Grb2-associated binding protein 1 + H2O GAB1 is cleaved during CV-B3 infection by viral proteinase 2A Coxsackievirus B3 ?
-
 ?
Grb2-associated binding protein 2 + H2O GAB2 is cleaved at G238 during CV-B3 infection by viral proteinase 2A, generating two cleaved fragments of GAB2-N1-237 and GAB2-C238-676 Coxsackievirus B3 GAB2-N1-237 + GAB2-C238-676
-
 ?
Grb2-associated binding protein 2 + H2O GAB2 is cleaved at G238 during CV-B3 infection by viral proteinase 2A, generating two cleaved fragments of GAB2-N1-237 and GAB2-C238-676. mutant GAB2G238E is non-cleavable for the enzyme Coxsackievirus B3 GAB2-N1-237 + GAB2-C238-676
-
 ?
additional information in vivo assays by expression of GAB2 proteins in virus-infected HeLa cells Coxsackievirus B3 ?
-
 ?

Synonyms

Synonyms Comment Organism
CV-B3 proteinase 2A
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 Coxsackievirus B3
proteinase 2A
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 Coxsackievirus B3

General Information

General Information Comment Organism
malfunction a catalytic mutant of 2A (2Amut) fails to cleave GAB2. Deletion of GAB1 causes a decrease in phosphorylated ERK1/2, but knockdown of GAB2 has no effect on virus-mediated ERK1/2 phosphorylation Coxsackievirus B3
physiological function Grb2-associated binding protein 2 (GAB2) is cleaved at G238 during CV-B3 infection by viral proteinase 2A. Knockdown of GAB2 significantly inhibits the synthesis of viral protein and subsequent viral progeny production, accompanied by reduced levels of phosphorylated p38, suggesting a pro-viral function for GAB2 linked to p38 activation. Expression of the cleavage products of GAB2 does not further enhance viral replication, indicating that GAB2 cleavage results in its loss-of-function, rather than gain-of-function in supporting viral replication that represents a distinct host defense mechanism Coxsackievirus B3