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Literature summary for 3.4.22.29 extracted from

  • Wu, S.; Wang, Y.; Lin, L.; Si, X.; Wang, T.; Zhong, X.; Tong, L.; Luan, Y.; Chen, Y.; Li, X.; Zhang, F.; Zhao, W.; Zhong, Z.
    Protease 2A induces stress granule formation during coxsackievirus B3 and enterovirus 71 infections (2015), Virol. J., 11, 192.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.29

Protein Variants

Protein Variants Comment Organism
D136N the mutant shows wild type cleavage efficiency toward eukaryotic initiation factor 4G Coxsackievirus B3
D136N the mutant shows wild type cleavage efficiency toward eukaryotic initiation factor 4G Enterovirus A71
D39E the mutant shows wild type cleavage efficiency toward eukaryotic initiation factor 4G Coxsackievirus B3
D39E the mutant shows wild type cleavage efficiency toward eukaryotic initiation factor 4G Enterovirus A71
G122E the mutant exhibits very low cleavage efficiency toward eukaryotic initiation factor 4G Coxsackievirus B3
G122E the mutant exhibits very low cleavage efficiency toward eukaryotic initiation factor 4G Enterovirus A71
L40F the mutant shows wild type cleavage efficiency toward eukaryotic initiation factor 4G Coxsackievirus B3
L40F the mutant shows wild type cleavage efficiency toward eukaryotic initiation factor 4G Enterovirus A71
S67F the mutant shows reduced cleavage efficiency toward eukaryotic initiation factor 4G Coxsackievirus B3
S67F the mutant shows reduced cleavage efficiency toward eukaryotic initiation factor 4G Enterovirus A71
V120M the mutant shows wild type cleavage efficiency toward eukaryotic initiation factor 4G Coxsackievirus B3
V120M the mutant shows wild type cleavage efficiency toward eukaryotic initiation factor 4G Enterovirus A71
Y89L the mutant shows wild type cleavage efficiency toward eukaryotic initiation factor 4G Coxsackievirus B3
Y89L the mutant shows wild type cleavage efficiency toward eukaryotic initiation factor 4G Enterovirus A71
Y90L the mutant shows reduced cleavage efficiency toward eukaryotic initiation factor 4G Coxsackievirus B3
Y90L the mutant shows reduced cleavage efficiency toward eukaryotic initiation factor 4G Enterovirus A71

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
eukaryotic initiation factor 4G + H2O Coxsackievirus B3
-
 ?
-
 ?
eukaryotic initiation factor 4G + H2O Enterovirus A71
-
 ?
-
 ?
eukaryotic initiation factor 4G + H2O Coxsackievirus B3 Woodruff
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Coxsackievirus B3 Q66282
-
-
Coxsackievirus B3 Woodruff Q66282
-
-
Enterovirus A71 Q66478
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
eukaryotic initiation factor 4G + H2O
-
 Coxsackievirus B3 ?
-
 ?
eukaryotic initiation factor 4G + H2O
-
 Enterovirus A71 ?
-
 ?
eukaryotic initiation factor 4G + H2O
-
 Coxsackievirus B3 Woodruff ?
-
 ?

Synonyms

Synonyms Comment Organism
2A protease
-
 Coxsackievirus B3
2A protease
-
 Enterovirus A71
2Apro
-
 Coxsackievirus B3
2Apro
-
 Enterovirus A71

General Information

General Information Comment Organism
physiological function 2A protease is the key viral component that triggers stress granule formation Coxsackievirus B3
physiological function 2A protease is the key viral component that triggers stress granule formation Enterovirus A71