Protein Variants | Comment | Organism |
---|---|---|
G60R | mutant is devoid of eIF4G cleavage activity | Enterovirus C |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Enterovirus C | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
eIF4G + H2O | - |
Enterovirus C | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
2A protease | - |
Enterovirus C |
2Apro | - |
Enterovirus C |
General Information | Comment | Organism |
---|---|---|
physiological function | cleavage of eIF4G by PV 2Apro in mammalian cells modifies the requirement for eIF2 in translation directed by picornavirus IRESs. Cleavage of eIF4G by PV 2Apro establishes a mechanism for IRES-driven translation that is cap- and eIF2 independent | Enterovirus C |