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Literature summary for 3.4.22.29 extracted from

  • Redondo, N.; Sanz, M.; Welnowska, E.; Carrasco, L.
    Translation without eiF2 promoted by poliovirus 2A protease (2011), PLoS ONE, 6, e25699.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
G60R mutant is devoid of eIF4G cleavage activity Enterovirus C

Organism

Organism UniProt Comment Textmining
Enterovirus C
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
eIF4G + H2O
-
Enterovirus C ?
-
?

Synonyms

Synonyms Comment Organism
2A protease
-
Enterovirus C
2Apro
-
Enterovirus C

General Information

General Information Comment Organism
physiological function cleavage of eIF4G by PV 2Apro in mammalian cells modifies the requirement for eIF2 in translation directed by picornavirus IRESs. Cleavage of eIF4G by PV 2Apro establishes a mechanism for IRES-driven translation that is cap- and eIF2 independent Enterovirus C