Literature summary for 3.4.22.29 extracted from

Glaser, W.; Triendl, A.; Skern, T.
The processing of eIF4GI by human rhinovirus type 2 2Apro: Relationship to self-cleavage and role of zinc (2003), J. Virol., 77, 5021-5025.

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Inhibitors

Inhibitors	Comment	Organism	Structure
N,N,N',N'-tetrakis-(2-pyridylmethyl)-ethylenediamine	at 0.005 mM inhibitor, 50% self-processing and eIFGI cleavage are observed at 60 min, whereas the control shows 50% cleavage at 30 min and almost complete cleavage at 60 min	Human rhinovirus sp.

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	the enzyme contains a structurally important zinc ion	Human rhinovirus sp.

Organism

Organism	UniProt	Comment	Textmining
Human rhinovirus sp.	-	serotypes 2	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	the enzyme is initially synthesized in an inactive form, self-processing is prerequisite for eIF4GI cleavage	Human rhinovirus sp.

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
eIF4G + H2O	self-processing is prerequisite for eIF4GI cleavage	Human rhinovirus sp.	?	-	?

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Release 2023.1 (January 2023)