Literature summary for 3.4.22.29 extracted from

Alvey, J.C.; Wyckoff, E.E.; Yu, S.F.; Lloyd, R.; Ehrenfeld, E.
cis- and trans-cleavage activities of poliovirus 2A protease expressed in Escherichia coli (1991), J. Virol., 65, 6077-6083.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Enterovirus C

Organism

Organism	UniProt	Comment	Textmining
Enterovirus C	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	infected	Enterovirus C	-
infected cell	infected Escherichia coli, containing plasmid pATH-2A	Enterovirus C	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
eukaryotic translation initiation factor 4F p220 subunit + H2O	in-trans activity	Enterovirus C	protein CPa + protein CPb	-	?
poliovirus polyprotein fragment + H2O	containing cleavage site at P1/P2 junction	Enterovirus C	hydrolyzed poliovirus polyprotein fragment	partially cleaved in trans	?
Ser-Thr-Lys-Asn-Leu-Thr-Thr-Gly-Phe-Gly-His-Gln-Asn-Lys-Ala + H2O	synthetic hexadecapeptide corresponding to P1/P2 junction	Enterovirus C	Ser-Thr-Lys-Asn-Leu-Thr-Thr-Tyr + Gly-Phe-Gly-His-Gln-Asn-Lys-Ala	-	?

Synonyms

Synonyms	Comment	Organism
poliovirus protease 2Apro	-	Enterovirus C

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Release 2023.1 (January 2023)