Organism | UniProt | Comment | Textmining |
---|---|---|---|
Coxsackievirus A21 | - |
CV-A21 | - |
Coxsackievirus B3 | - |
CV-B3 | - |
Enterovirus A71 | - |
EV-A71 | - |
Enterovirus D68 | - |
EV-D68 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | the virus is propagated in HeLa R19 cells | Coxsackievirus B3 | - |
additional information | the virus is propagated in HeLa R19 cells | Enterovirus A71 | - |
additional information | the virus is propagated in HeLa R19 cells | Enterovirus D68 | - |
additional information | the virus is propagated in HeLa R19 cells | Coxsackievirus A21 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | no activity with cellular protein MAVS | Coxsackievirus B3 | ? | - |
? | |
additional information | no activity with cellular protein MAVS | Enterovirus A71 | ? | - |
? | |
additional information | no activity with cellular protein MAVS | Enterovirus D68 | ? | - |
? | |
additional information | no activity with cellular protein MAVS | Coxsackievirus A21 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3C protease | - |
Coxsackievirus B3 |
3C protease | - |
Enterovirus A71 |
3C protease | - |
Enterovirus D68 |
3C protease | - |
Coxsackievirus A21 |
3Cpro | - |
Coxsackievirus B3 |
3Cpro | - |
Enterovirus A71 |
3Cpro | - |
Enterovirus D68 |
3Cpro | - |
Coxsackievirus A21 |
enterovirus 3C protease | - |
Coxsackievirus B3 |
enterovirus 3C protease | - |
Enterovirus A71 |
enterovirus 3C protease | - |
Enterovirus D68 |
enterovirus 3C protease | - |
Coxsackievirus A21 |
General Information | Comment | Organism |
---|---|---|
metabolism | during enterovirus infection, several signaling molecules in the RLR pathway have been suggested to be cleaved by 2Apro and 3Cpro (EC 3.4.22.28). 2Apro is the viral protease responsible for cleaving MAVS. Addition of recombinant 2Apro, but not 3Cpro, to cell lysates results in the appearance of MAVS cleavage products of the same size as those observed in infected cells. These cleavage products are also observed when 2Apro, but not 3Cpro, is expressed by a recombinant encephalomyocarditis virus (EMCV), a picornavirus that by itself does not cleave components of the RLR pathway. 3Cpro, when expressed by a recombinant EMCV, fails to cleave the cellular protein MAVS. Enterovirus enzyme 2Apro, but not 3Cpro, suppresses the induction of IFN-alpha/beta gene transcription in HeLa cells | Coxsackievirus B3 |
physiological function | enterovirus 3Cpro plays a key role in inhibiting innate antiviral cellular responses. During enterovirus infection, several signaling molecules in the RLR pathway have been suggested to be cleaved by 2Apro and 3Cpro (EC 3.4.22.28). Enterovirus enzyme 2Apro, but not 3Cpro, suppresses the induction of IFN-alpha/beta gene transcription in HeLa cells | Enterovirus A71 |
physiological function | enterovirus 3Cpro plays a key role in inhibiting innate antiviral cellular responses. During enterovirus infection, several signaling molecules in the RLR pathway have been suggested to be cleaved by 2Apro and 3Cpro (EC 3.4.22.28). Enterovirus enzyme 2Apro, but not 3Cpro, suppresses the induction of IFN-alpha/beta gene transcription in HeLa cells | Enterovirus D68 |
physiological function | enterovirus 3Cpro plays a key role in inhibiting innate antiviral cellular responses. During enterovirus infection, several signaling molecules in the RLR pathway have been suggested to be cleaved by 2Apro and 3Cpro (EC 3.4.22.28). Enterovirus enzyme 2Apro, but not 3Cpro, suppresses the induction of IFN-alpha/beta gene transcription in HeLa cells | Coxsackievirus A21 |