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Literature summary for 3.4.22.28 extracted from

  • Zhou, Z.; Mogensen, M.M.; Powell, P.P.; Curry, S.; Wileman, T.
    Foot-and-mouth disease virus 3C protease induces fragmentation of the Golgi compartment and blocks intra-Golgi transport (2013), J. Virol., 87, 11721-11729.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.28

Protein Variants

Protein Variants Comment Organism
C142A active mutant Foot-and-mouth disease virus
C142L active mutant Foot-and-mouth disease virus
C142S active mutant Foot-and-mouth disease virus
C163L inactive mutant Foot-and-mouth disease virus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ERGIC53 protein + H2O Foot-and-mouth disease virus
-
 ?
-
 ?
membrin + H2O Foot-and-mouth disease virus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Foot-and-mouth disease virus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ERGIC53 protein + H2O
-
 Foot-and-mouth disease virus ?
-
 ?
membrin + H2O
-
 Foot-and-mouth disease virus ?
-
 ?

Synonyms

Synonyms Comment Organism
3C protease
-
 Foot-and-mouth disease virus
3Cpro
-
 Foot-and-mouth disease virus

General Information

General Information Comment Organism
physiological function the enzyme induces fragmentation of the Golgi compartment and blocks intra-Golgi transport. Inhibition of microtubule re-growth also requires the enzyme's protease activity. The block of intra-Golgi transport is imposed by separate actions of the enzyme possibly through degradation of proteins required for intra-Golgi transport Foot-and-mouth disease virus