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Literature summary for 3.4.22.28 extracted from

  • Lu, G.; Qi, J.; Chen, Z.; Xu, X.; Gao, F.; Lin, D.; Qian, W.; Liu, H.; Jiang, H.; Yan, J.; Gao, G.F.
    Enterovirus 71 and coxsackievirus A16 3C proteases: binding to rupintrivir and their substrates and anti-hand, foot, and mouth disease virus drug design (2011), J. Virol., 85, 10319-10331.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Enterovirus A71
expressed in Escherichia coli Coxsackievirus A16

Protein Variants

Protein Variants Comment Organism
C147A catalytically inactive mutant is successfully crystallized in the presence of peptide KPVLRTATVQGPSLDF. Mutant also folds into two domains and exhibits extremely high structural similarity to its coxsackievirus counterpart Enterovirus A71
C147A catalytically inactive mutant is successfully crystallized in the presence of peptide KPVLRTATVQGPSLDF. Mutant also folds into two domains and exhibits extremely high structural similarity to its coxsackievirus counterpart Coxsackievirus A16

Inhibitors

Inhibitors Comment Organism Structure
rupintrivir
-
Coxsackievirus A16
rupintrivir
-
Enterovirus A71

Organism

Organism UniProt Comment Textmining
Coxsackievirus A16
-
-
-
Enterovirus A71
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Dabcyl-KIGNTIEALFQGPPKFRE-EDANS + H2O
-
Enterovirus A71 Dabcyl-KIGNTIEALFQ + GPPKFRE-EDANS
-
?
Dabcyl-KIGNTIEALFQGPPKFRE-EDANS + H2O
-
Coxsackievirus A16 Dabcyl-KIGNTIEALFQ + GPPKFRE-EDANS
-
?
FAGLAQAVTQGFPTEL + H2O mutated peptide, cleavage efficacy (micromol/l/min): 2.7 Enterovirus A71 FAGLAQAVTQ + GFPTEL
-
?
FAGLAQAVTQGFPTEL + H2O mutated peptide, cleavage efficacy (micromol/l/min): 2.93 Coxsackievirus A16 FAGLAQAVTQ + GFPTEL
-
?
FAGLRAAVTQGFPTEL + H2O mutated peptide, cleavage efficacy (micromol/l/min): 4.11 Enterovirus A71 FAGLRAAVTQ + GFPTEL
-
?
FAGLRAAVTQGFPTEL + H2O mutated peptide, cleavage efficacy (micromol/l/min): 4.45 Coxsackievirus A16 FAGLRAAVTQ + GFPTEL
-
?
FAGLRQAVEQGFPTEL + H2O mutated peptide, cleavage efficacy (micromol/l/min): 3.65 Enterovirus A71 FAGLRQAVEQ + GFPTEL
-
?
FAGLRQAVEQGFPTEL + H2O mutated peptide, cleavage efficacy (micromol/l/min): 3.79 Coxsackievirus A16 FAGLRQAVEQ + GFPTEL
-
?
FAGLRQAVFQGFPTEL + H2O mutated peptide, cleavage efficacy (micromol/l/min): 14.22 Enterovirus A71 FAGLRQAVFQ + GFPTEL
-
?
FAGLRQAVFQGFPTEL + H2O mutated peptide, cleavage efficacy (micromol/l/min): 18.65 Coxsackievirus A16 FAGLRQAVFQ + GFPTEL
-
?
FAGLRQAVKQGFPTEL + H2O mutated peptide, cleavage efficacy (micromol/l/min): 0.902 Enterovirus A71 FAGLRQAVKQ + GFPTEL
-
?
FAGLRQAVKQGFPTEL + H2O mutated peptide, cleavage efficacy (micromol/l/min): 0.902 Coxsackievirus A16 FAGLRQAVKQ + GFPTEL
-
?
FAGLRQAVKQGIPTEL + H2O cleavage efficacy (micromol/l/min): 0.3 Enterovirus A71 FAGLRQAVKQ + GIPTEL
-
?
FAGLRQAVKQGIPTEL + H2O cleavage efficacy (micromol/l/min): 0.3 Coxsackievirus A16 FAGLRQAVKQ + GIPTEL
-
?
FAGLRQAVTQGFPTEL + H2O cleavage efficacy (micromol/l/min): 5.77 Coxsackievirus A16 FAGLRQAVTQ + GFPTEL
-
?
FAGLRQAVTQGFPTEL + H2O reference peptide, cleavage efficacy (micromol/l/min): 5.08 Enterovirus A71 FAGLRQAVTQ + GFPTEL
-
?
FAGLRQAVTQSFPTEL + H2O mutated peptide, cleavage efficacy (micromol/l/min): 0.21 Enterovirus A71 FAGLRQAVTQ + SFPTEL
-
?
FAGLRQAVTQSFPTEL + H2O mutated peptide, cleavage efficacy (micromol/l/min): 0.27 Coxsackievirus A16 FAGLRQAVTQ + SFPTEL
-
?
IGNTIEALFQGPPKFR + H2O cleavage efficacy (micromol/l/min): 10.72 Coxsackievirus A16 IGNTIEALFQ + GPPKFR
-
?
IGNTIEALFQGPPKFR + H2O cleavage efficacy (micromol/l/min): 8.37 Enterovirus A71 IGNTIEALFQ + GPPKFR
-
?
ILGIPIVQKQSASWLK + H2O cleavage efficacy (micromol/l/min): 0.055 Enterovirus A71 ILGIPIVQKQ + SASWLK
-
?
ILGIPIVQKQSASWLK + H2O cleavage efficacy (micromol/l/min): 0.063 Coxsackievirus A16 ILGIPIVQKQ + SASWLK
-
?
KPVLRTATVQGPSLDF + H2O cleavage efficacy (micromol/l/min): 4.1 Enterovirus A71 KPVLRTATVQ + GPSLDF
-
?
KPVLRTATVQGPSLDF + H2O cleavage efficacy (micromol/l/min): 4.3 Coxsackievirus A16 KPVLRTATVQ + GPSLDF
-
?
LKRGYFASEQGEIQWM + H2O cleavage efficacy (micromol/l/min): 5.01 Enterovirus A71 LKRGYFASEQ + GEIQWM
-
?
LKRGYFASEQGEIQWM + H2O cleavage efficacy (micromol/l/min): 5.09 Coxsackievirus A16 LKRGYFASEQ + GEIQWM
-
?
LKRSYFASEQGEIQWV + H2O cleavage efficacy (micromol/l/min): 8.26 Enterovirus A71 LKRSYFASEQ + GEIQWV
-
?
LKRSYFASEQGEIQWV + H2O cleavage efficacy (micromol/l/min): 9.78 Coxsackievirus A16 LKRSYFASEQ + GEIQWV
-
?
LWLDEEAMEQGVSDYI + H2O cleavage efficacy (micromol/l/min): 0.22 Enterovirus A71 LWLDEEAMEQ + GVSDYI
-
?
LWLDEEAMEQGVSDYI + H2O cleavage efficacy (micromol/l/min): 0.23 Coxsackievirus A16 LWLDEEAMEQ + GVSDYI
-
?
VIYKLFAGFQGAYSGA + H2O cleavage efficacy (micromol/l/min): 0.56 Enterovirus A71 VIYKLFAGFQ + GAYSGA
-
?
VIYKLFAGFQGAYSGA + H2O cleavage efficacy (micromol/l/min): 0.63 Coxsackievirus A16 VIYKLFAGFQ + GAYSGA
-
?

Synonyms

Synonyms Comment Organism
3C protease
-
Enterovirus A71
3C protease
-
Coxsackievirus A16

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Enterovirus A71
25
-
assay at Coxsackievirus A16

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
assay at Enterovirus A71
6.5
-
assay at Coxsackievirus A16

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00165
-
pH 6.5, 25°C Enterovirus A71 rupintrivir
0.002
-
pH 6.5, 25°C Coxsackievirus A16 rupintrivir