Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Enterovirus A71 |
expressed in Escherichia coli | Coxsackievirus A16 |
Protein Variants | Comment | Organism |
---|---|---|
C147A | catalytically inactive mutant is successfully crystallized in the presence of peptide KPVLRTATVQGPSLDF. Mutant also folds into two domains and exhibits extremely high structural similarity to its coxsackievirus counterpart | Enterovirus A71 |
C147A | catalytically inactive mutant is successfully crystallized in the presence of peptide KPVLRTATVQGPSLDF. Mutant also folds into two domains and exhibits extremely high structural similarity to its coxsackievirus counterpart | Coxsackievirus A16 |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
rupintrivir | - |
Coxsackievirus A16 | |
rupintrivir | - |
Enterovirus A71 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Coxsackievirus A16 | - |
- |
- |
Enterovirus A71 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Dabcyl-KIGNTIEALFQGPPKFRE-EDANS + H2O | - |
Enterovirus A71 | Dabcyl-KIGNTIEALFQ + GPPKFRE-EDANS | - |
? | |
Dabcyl-KIGNTIEALFQGPPKFRE-EDANS + H2O | - |
Coxsackievirus A16 | Dabcyl-KIGNTIEALFQ + GPPKFRE-EDANS | - |
? | |
FAGLAQAVTQGFPTEL + H2O | mutated peptide, cleavage efficacy (micromol/l/min): 2.7 | Enterovirus A71 | FAGLAQAVTQ + GFPTEL | - |
? | |
FAGLAQAVTQGFPTEL + H2O | mutated peptide, cleavage efficacy (micromol/l/min): 2.93 | Coxsackievirus A16 | FAGLAQAVTQ + GFPTEL | - |
? | |
FAGLRAAVTQGFPTEL + H2O | mutated peptide, cleavage efficacy (micromol/l/min): 4.11 | Enterovirus A71 | FAGLRAAVTQ + GFPTEL | - |
? | |
FAGLRAAVTQGFPTEL + H2O | mutated peptide, cleavage efficacy (micromol/l/min): 4.45 | Coxsackievirus A16 | FAGLRAAVTQ + GFPTEL | - |
? | |
FAGLRQAVEQGFPTEL + H2O | mutated peptide, cleavage efficacy (micromol/l/min): 3.65 | Enterovirus A71 | FAGLRQAVEQ + GFPTEL | - |
? | |
FAGLRQAVEQGFPTEL + H2O | mutated peptide, cleavage efficacy (micromol/l/min): 3.79 | Coxsackievirus A16 | FAGLRQAVEQ + GFPTEL | - |
? | |
FAGLRQAVFQGFPTEL + H2O | mutated peptide, cleavage efficacy (micromol/l/min): 14.22 | Enterovirus A71 | FAGLRQAVFQ + GFPTEL | - |
? | |
FAGLRQAVFQGFPTEL + H2O | mutated peptide, cleavage efficacy (micromol/l/min): 18.65 | Coxsackievirus A16 | FAGLRQAVFQ + GFPTEL | - |
? | |
FAGLRQAVKQGFPTEL + H2O | mutated peptide, cleavage efficacy (micromol/l/min): 0.902 | Enterovirus A71 | FAGLRQAVKQ + GFPTEL | - |
? | |
FAGLRQAVKQGFPTEL + H2O | mutated peptide, cleavage efficacy (micromol/l/min): 0.902 | Coxsackievirus A16 | FAGLRQAVKQ + GFPTEL | - |
? | |
FAGLRQAVKQGIPTEL + H2O | cleavage efficacy (micromol/l/min): 0.3 | Enterovirus A71 | FAGLRQAVKQ + GIPTEL | - |
? | |
FAGLRQAVKQGIPTEL + H2O | cleavage efficacy (micromol/l/min): 0.3 | Coxsackievirus A16 | FAGLRQAVKQ + GIPTEL | - |
? | |
FAGLRQAVTQGFPTEL + H2O | cleavage efficacy (micromol/l/min): 5.77 | Coxsackievirus A16 | FAGLRQAVTQ + GFPTEL | - |
? | |
FAGLRQAVTQGFPTEL + H2O | reference peptide, cleavage efficacy (micromol/l/min): 5.08 | Enterovirus A71 | FAGLRQAVTQ + GFPTEL | - |
? | |
FAGLRQAVTQSFPTEL + H2O | mutated peptide, cleavage efficacy (micromol/l/min): 0.21 | Enterovirus A71 | FAGLRQAVTQ + SFPTEL | - |
? | |
FAGLRQAVTQSFPTEL + H2O | mutated peptide, cleavage efficacy (micromol/l/min): 0.27 | Coxsackievirus A16 | FAGLRQAVTQ + SFPTEL | - |
? | |
IGNTIEALFQGPPKFR + H2O | cleavage efficacy (micromol/l/min): 10.72 | Coxsackievirus A16 | IGNTIEALFQ + GPPKFR | - |
? | |
IGNTIEALFQGPPKFR + H2O | cleavage efficacy (micromol/l/min): 8.37 | Enterovirus A71 | IGNTIEALFQ + GPPKFR | - |
? | |
ILGIPIVQKQSASWLK + H2O | cleavage efficacy (micromol/l/min): 0.055 | Enterovirus A71 | ILGIPIVQKQ + SASWLK | - |
? | |
ILGIPIVQKQSASWLK + H2O | cleavage efficacy (micromol/l/min): 0.063 | Coxsackievirus A16 | ILGIPIVQKQ + SASWLK | - |
? | |
KPVLRTATVQGPSLDF + H2O | cleavage efficacy (micromol/l/min): 4.1 | Enterovirus A71 | KPVLRTATVQ + GPSLDF | - |
? | |
KPVLRTATVQGPSLDF + H2O | cleavage efficacy (micromol/l/min): 4.3 | Coxsackievirus A16 | KPVLRTATVQ + GPSLDF | - |
? | |
LKRGYFASEQGEIQWM + H2O | cleavage efficacy (micromol/l/min): 5.01 | Enterovirus A71 | LKRGYFASEQ + GEIQWM | - |
? | |
LKRGYFASEQGEIQWM + H2O | cleavage efficacy (micromol/l/min): 5.09 | Coxsackievirus A16 | LKRGYFASEQ + GEIQWM | - |
? | |
LKRSYFASEQGEIQWV + H2O | cleavage efficacy (micromol/l/min): 8.26 | Enterovirus A71 | LKRSYFASEQ + GEIQWV | - |
? | |
LKRSYFASEQGEIQWV + H2O | cleavage efficacy (micromol/l/min): 9.78 | Coxsackievirus A16 | LKRSYFASEQ + GEIQWV | - |
? | |
LWLDEEAMEQGVSDYI + H2O | cleavage efficacy (micromol/l/min): 0.22 | Enterovirus A71 | LWLDEEAMEQ + GVSDYI | - |
? | |
LWLDEEAMEQGVSDYI + H2O | cleavage efficacy (micromol/l/min): 0.23 | Coxsackievirus A16 | LWLDEEAMEQ + GVSDYI | - |
? | |
VIYKLFAGFQGAYSGA + H2O | cleavage efficacy (micromol/l/min): 0.56 | Enterovirus A71 | VIYKLFAGFQ + GAYSGA | - |
? | |
VIYKLFAGFQGAYSGA + H2O | cleavage efficacy (micromol/l/min): 0.63 | Coxsackievirus A16 | VIYKLFAGFQ + GAYSGA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3C protease | - |
Enterovirus A71 |
3C protease | - |
Coxsackievirus A16 |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Enterovirus A71 |
25 | - |
assay at | Coxsackievirus A16 |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
assay at | Enterovirus A71 |
6.5 | - |
assay at | Coxsackievirus A16 |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00165 | - |
pH 6.5, 25°C | Enterovirus A71 | rupintrivir | |
0.002 | - |
pH 6.5, 25°C | Coxsackievirus A16 | rupintrivir |