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Literature summary for 3.4.22.28 extracted from

  • Ramajayam, R.; Tan, K.P.; Liu, H.G.; Liang, P.H.
    Synthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease inhibitors (2010), Bioorg. Med. Chem., 18, 7849-7854.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,3-diphenyl-4-(4-carboxybenzylidene)pyrazol-5(4H)-one
-
Coxsackievirus B3
1,3-diphenyl-4-(4-carboxybenzylidene)pyrazol-5(4H)-one
-
Severe acute respiratory syndrome-related coronavirus
3-phenyl-1-(3,4-dichlorophenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one
-
Coxsackievirus B3
3-phenyl-1-(3,4-dichlorophenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one
-
Severe acute respiratory syndrome-related coronavirus
3-phenyl-1-(3-chlorophenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one
-
Coxsackievirus B3
3-phenyl-1-(3-chlorophenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one
-
Severe acute respiratory syndrome-related coronavirus
3-phenyl-1-(3-nitrophenyl)-4-(4-carboxybenzylidene)-pyrazol-5(4H)-one
-
Coxsackievirus B3
3-phenyl-1-(3-nitrophenyl)-4-(4-carboxybenzylidene)-pyrazol-5(4H)-one
-
Severe acute respiratory syndrome-related coronavirus
3-phenyl-1-(4-chlorophenyl)-4-(4-carboxybenzylidene)-pyrazol-5(4H)-one
-
Coxsackievirus B3
3-phenyl-1-(4-chlorophenyl)-4-(4-carboxybenzylidene)-pyrazol-5(4H)-one
-
Severe acute respiratory syndrome-related coronavirus
3-phenyl-1-(4-cyanophenyl)-4-(4-carboxybenzylidene)-pyrazol-5(4H)-one
-
Coxsackievirus B3
3-phenyl-1-(4-cyanophenyl)-4-(4-carboxybenzylidene)-pyrazol-5(4H)-one
-
Severe acute respiratory syndrome-related coronavirus
3-phenyl-1-(4-fluorophenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one
-
Coxsackievirus B3
3-phenyl-1-(4-fluorophenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one
-
Severe acute respiratory syndrome-related coronavirus
3-phenyl-1-(4-methoxyphenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one
-
Coxsackievirus B3
3-phenyl-1-(4-methoxyphenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one
-
Severe acute respiratory syndrome-related coronavirus
3-phenyl-1-(4-trifluoromethoxyphenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one
-
Coxsackievirus B3
3-phenyl-1-(4-trifluoromethoxyphenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one
-
Severe acute respiratory syndrome-related coronavirus

Organism

Organism UniProt Comment Textmining
Coxsackievirus B3
-
-
-
Severe acute respiratory syndrome-related coronavirus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Dabcyl-KTSAVLQSGFRKME-EDANS + H2O
-
Severe acute respiratory syndrome-related coronavirus Dabcyl-KTSAVL + QSGFRKME-EDANS
-
?
Dabcyl-KTSAVLQSGFRKME-EDANS + H2O
-
Coxsackievirus B3 Dabcyl-KTSAVL + QSGFRKME-EDANS
-
?

Synonyms

Synonyms Comment Organism
3C-like protease
-
Severe acute respiratory syndrome-related coronavirus
3C-like protease
-
Coxsackievirus B3

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Severe acute respiratory syndrome-related coronavirus
25
-
assay at Coxsackievirus B3

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Severe acute respiratory syndrome-related coronavirus
7
-
assay at Coxsackievirus B3

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.005
-
pH 7, 25°C Severe acute respiratory syndrome-related coronavirus 3-phenyl-1-(4-cyanophenyl)-4-(4-carboxybenzylidene)-pyrazol-5(4H)-one
0.0068
-
pH 7, 25°C Severe acute respiratory syndrome-related coronavirus 3-phenyl-1-(4-fluorophenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one
0.0084
-
pH 7, 25°C Severe acute respiratory syndrome-related coronavirus 3-phenyl-1-(3-nitrophenyl)-4-(4-carboxybenzylidene)-pyrazol-5(4H)-one
0.0096
-
pH 7, 25°C Coxsackievirus B3 3-phenyl-1-(3-nitrophenyl)-4-(4-carboxybenzylidene)-pyrazol-5(4H)-one
0.01
-
pH 7, 25°C Severe acute respiratory syndrome-related coronavirus 3-phenyl-1-(3-chlorophenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one
0.012
-
pH 7, 25°C Severe acute respiratory syndrome-related coronavirus 3-phenyl-1-(4-methoxyphenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one
0.013
-
pH 7, 25°C Severe acute respiratory syndrome-related coronavirus 3-phenyl-1-(4-chlorophenyl)-4-(4-carboxybenzylidene)-pyrazol-5(4H)-one
0.0166
-
pH 7, 25°C Coxsackievirus B3 3-phenyl-1-(4-methoxyphenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one
0.017
-
pH 7, 25°C Coxsackievirus B3 3-phenyl-1-(3-chlorophenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one
0.018
-
pH 7, 25°C Severe acute respiratory syndrome-related coronavirus 1,3-diphenyl-4-(4-carboxybenzylidene)pyrazol-5(4H)-one
0.02
-
pH 7, 25°C Coxsackievirus B3 3-phenyl-1-(4-cyanophenyl)-4-(4-carboxybenzylidene)-pyrazol-5(4H)-one
0.022
-
pH 7, 25°C Coxsackievirus B3 3-phenyl-1-(4-fluorophenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one
0.024
-
pH 7, 25°C Severe acute respiratory syndrome-related coronavirus 3-phenyl-1-(3,4-dichlorophenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one
0.025
-
pH 7, 25°C Coxsackievirus B3 3-phenyl-1-(4-chlorophenyl)-4-(4-carboxybenzylidene)-pyrazol-5(4H)-one
0.042
-
pH 7, 25°C Severe acute respiratory syndrome-related coronavirus 3-phenyl-1-(4-trifluoromethoxyphenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one
0.051
-
pH 7, 25°C Coxsackievirus B3 1,3-diphenyl-4-(4-carboxybenzylidene)pyrazol-5(4H)-one
0.098
-
pH 7, 25°C Coxsackievirus B3 3-phenyl-1-(4-trifluoromethoxyphenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one
0.125
-
pH 7, 25°C Coxsackievirus B3 3-phenyl-1-(3,4-dichlorophenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one