Application | Comment | Organism |
---|---|---|
medicine | attractive target for antiviral drugs | Hepatovirus A |
Crystallization (Comment) | Organism |
---|---|
hanging drop vapor diffusion method at room temperature, to 1.5 A resolution | Hepatovirus A |
Protein Variants | Comment | Organism |
---|---|---|
C24S | intact active site Cys172, displays the same catalytic properties as the wild-type enzyme | Hepatovirus A |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
13C-labeled beta-lactone | - |
Hepatovirus A | |
N-Cbz-L-serine beta-lactone | irreversible inhibitor, associated with His 102 of the enzyme | Hepatovirus A | |
N-iodoacetyl-Val-Phe-amide | irreversible inhibitor, alkylates the active site cysteine 172 | Hepatovirus A |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Hepatovirus A | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Dabcyl-GLRTQSFS-EDANS + H2O | fluorogenic substrate, hydrolysis at the glutamine residue | Hepatovirus A | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3C protease | - |
Hepatovirus A |