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Literature summary for 3.4.22.28 extracted from

  • Johnson, T.O.; Hua, Y.; Luu, H.T.; Brown, E.L.; Chan, F.; Chu, S.S.; Dragovich, P.S.; Eastman, B.W.; Ferre, R.A.; Fuhrman, S.A.; Hendrickson, T.F.; Maldonado, F.C.; Matthews, D.A.; Meador, J.W., 3rd; Patick, A.K.; Reich, S.H.; Skalitzky, D.J.; Worland, S.T.; Yang, M.; Zalman, L.S.
    Structure-based design of a parallel synthetic array directed toward the discovery of irreversible inhibitors of human rhinovirus 3C protease (2002), J. Med. Chem., 45, 2016-2023.
    View publication on PubMed
Search for more literature for 3.4.22.28

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure of inhibitors covalently bound to the enzyme, hanging drop vapor diffusion method enterovirus

Inhibitors

Inhibitors Comment Organism Structure
4S-(3-benzo[1,3]dioxol-5-yl-acryloylamino)-5-(2-oxopyrrolidin-3S-yl)pent-2-enoic acid ethyl ester
-
 enterovirus
4S-[(2H-chromene-3-carbonyl)amino]-5-(2-oxopyrrolidin-3S-yl)pent-2-enoic acid ethyl ester
-
 enterovirus
4S-[(2methyl-5-phenylfuran-3-carbonyl)amino]-5-(2-oxopyrrolidin-3S-yl)pent-2-enoic acid ethyl ester
-
 enterovirus
4S-[(6-bromo-2H-chromene-3-carbonyl)amino]-5-(2-oxopyrrolidin-3S-yl)pent-2-enoic acid ethyl ester
-
 enterovirus
4S-[(6-chloro-2H-chromene-3-carbonyl)amino]-5-(2-oxopyrrolidin-3S-yl)pent-2-enoic acid ethyl ester
-
 enterovirus
4S-[(6-methyl-naphthalene-2-carbonyl)amino]-5-(2-oxopyrrolidin-3S-yl)pent-2-enoic acid ethyl ester
-
 enterovirus
4S-[(7-bromonaphthalene-2-carbonyl)amino]-5-(2-oxopyrrolidin-3S-yl)-pent-2-enoic acid ethyl ester
-
 enterovirus
4S-[(naphthalene-2-carbonyl)amino]-5-(2-oxopyrrolidin-3S-yl)pent-2-enoic acid
-
 enterovirus
4S-[3-(2,5-dibromophenyl)acryloylamino]-5-(2-oxopyrolidin-3S-yl)pent-2-enoic acid ethyl ester
-
 enterovirus
4S-[3-(3-bromo-4-fluorophenyl)acryloylamino]-5-(2-oxopyrrolidin-3S-yl)pent-2-enoic acid ethyl ester
-
 enterovirus
4S-[3-(3-bromo-4-methyl-phenyl)-acryloylamino]-5-(2-oxopyrrolidin-3S-yl)pent-2-enoic acid ethyl ester
-
 enterovirus
4S-[3-(3-bromophenyl)acryloylamino]-5-(2-oxopyrrolidin-3S-yl)pent-2-enoic acid ethyl ester
-
 enterovirus
4S-[3-(6'-bromo-benzo[1,3]dioxol-5-yl)acryloylamino]-5-(2-oxopyrrolidin-3S-yl)pent-2-enoic acid
-
 enterovirus

Organism

Organism UniProt Comment Textmining
enterovirus
-
 human rhinovirus 14
-