Protein Variants | Comment | Organism |
---|---|---|
C24S | mutant enzyme in which the nonessential surface cysteine is replaced with serine and which exhibits catalytic parameters identical to those of wild-type enzyme | Hepatovirus A |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4S)-4-(acetylamino)-N,N-dimethyl-5-oxopentanamide | hepatitis A virus | Hepatovirus A | |
acetyl-Ala-Ala-Ala-(N,N'-dimethylglutaminal) | - |
Hepatovirus A | |
acetyl-Leu-Ala-Ala-(N,N'-dimethylglutaminal) | - |
Hepatovirus A | |
additional information | no inhibition by acetyl-Leu-Ala-Ala-Gln'-thioester | enterovirus | |
additional information | no inhibition by acetyl-Leu-Ala-Ala-Gln'-thioester | Hepatovirus A |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
enterovirus | - |
recombinant enzyme | - |
Hepatovirus A | - |
recombinant enzyme | - |
Hepatovirus A | - |
wild-type and 3 mutants: C24S | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-Arg-Pro-Val-Val-Val-Gln-Gly-Pro-Asn-NH2 + H2O | human rhinovirus | enterovirus | ? | - |
? | |
acetyl-Glu-Leu-Arg-Thr-Gln-Ser-Phe-Ser-NH2 + H2O | hepatitis A virus | Hepatovirus A | ? | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000042 | - |
acetyl-Leu-Ala-Ala-(N,N'-dimethylglutaminal) | 25°C, mutant enzyme C24S | Hepatovirus A |