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Literature summary for 3.4.22.28 extracted from
- Viral proteinases (1988), Annu. Rev. Biochem., 57, 701-754.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Foot-and-mouth disease virus |
- |
Enterovirus C |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| iodoacetamide | - |
coxsackievirus |  |
| iodoacetamide | - |
echovirus | |
| iodoacetamide | - |
Encephalomyocarditis virus | |
| iodoacetamide | - |
enterovirus | |
| iodoacetamide | - |
Enterovirus C | |
| iodoacetamide | - |
Enterovirus E | |
| iodoacetamide | - |
Foot-and-mouth disease virus | |
| iodoacetamide | - |
Hepatovirus A | |
| iodoacetamide | - |
picornaviridae | |
| NEM | - |
coxsackievirus | |
| NEM | - |
echovirus | |
| NEM | - |
Encephalomyocarditis virus | |
| NEM | - |
enterovirus | |
| NEM | - |
Enterovirus C | |
| NEM | - |
Enterovirus E | |
| NEM | - |
Foot-and-mouth disease virus | |
| NEM | - |
Hepatovirus A | |
| NEM | - |
picornaviridae | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| picornavirus polyprotein + H2O | Foot-and-mouth disease virus | involved in proteolytic processing of virus polyprotein | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | Enterovirus C | involved in proteolytic processing of virus polyprotein | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | Encephalomyocarditis virus | involved in proteolytic processing of virus polyprotein | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | enterovirus | involved in proteolytic processing of virus polyprotein | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | Hepatovirus A | involved in proteolytic processing of virus polyprotein | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | coxsackievirus | involved in proteolytic processing of virus polyprotein | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | Enterovirus E | involved in proteolytic processing of virus polyprotein | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | echovirus | involved in proteolytic processing of virus polyprotein | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | picornaviridae | involved in proteolytic processing of virus polyprotein | hydrolyzed picornavirus polyprotein | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| coxsackievirus | - |
- |
- |
| echovirus | - |
- |
- |
| Encephalomyocarditis virus | - |
- |
- |
| enterovirus | - |
human rhinovirus | - |
| Enterovirus C | - |
- |
- |
| Enterovirus E | - |
- |
- |
| Foot-and-mouth disease virus | - |
- |
- |
| Hepatovirus A | - |
- |
- |
| picornaviridae | - |
overview | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dansyl-Glu-Glu-Glu-Ala-Met-Glu-Gly-Ile-Thr-Asn-Lys-NH2 + H2O | i.e. peptide corresponding to cleavage site between poliovirus polypeptides 2A and 2B | Enterovirus C | dansyl-Glu-Glu-Glu-Ala-Met-Glu + Gly-Ile-Thr-Asn-Lys-NH2 | - |
? | |
| L-P1-2A precursor polypeptide of encephalomyocarditis virus + H2O | cardioviruses | Encephalomyocarditis virus | peptide P1-2A | - |
? | |
| additional information | no hydrolysis of cellular proteins during viral infection | Foot-and-mouth disease virus | ? | - |
? | |
| additional information | no hydrolysis of cellular proteins during viral infection | Enterovirus C | ? | - |
? | |
| additional information | no hydrolysis of cellular proteins during viral infection | Encephalomyocarditis virus | ? | - |
? | |
| additional information | no hydrolysis of cellular proteins during viral infection | enterovirus | ? | - |
? | |
| additional information | no hydrolysis of cellular proteins during viral infection | Hepatovirus A | ? | - |
? | |
| additional information | no hydrolysis of cellular proteins during viral infection | coxsackievirus | ? | - |
? | |
| additional information | no hydrolysis of cellular proteins during viral infection | Enterovirus E | ? | - |
? | |
| additional information | no hydrolysis of cellular proteins during viral infection | echovirus | ? | - |
? | |
| additional information | no hydrolysis of cellular proteins during viral infection | picornaviridae | ? | - |
? | |
| additional information | no maturation cleavage in picornavirus replication | Foot-and-mouth disease virus | ? | - |
? | |
| additional information | no maturation cleavage in picornavirus replication | Enterovirus C | ? | - |
? | |
| additional information | no maturation cleavage in picornavirus replication | Encephalomyocarditis virus | ? | - |
? | |
| additional information | no maturation cleavage in picornavirus replication | enterovirus | ? | - |
? | |
| additional information | no maturation cleavage in picornavirus replication | Hepatovirus A | ? | - |
? | |
| additional information | no maturation cleavage in picornavirus replication | coxsackievirus | ? | - |
? | |
| additional information | no maturation cleavage in picornavirus replication | Enterovirus E | ? | - |
? | |
| additional information | no maturation cleavage in picornavirus replication | echovirus | ? | - |
? | |
| additional information | no maturation cleavage in picornavirus replication | picornaviridae | ? | - |
? | |
| P1-2A precursor polypeptide of encephalomyocarditis virus + H2O | cardio- and aphthoviruses | Encephalomyocarditis virus | peptide P1 + peptide 2A | - |
? | |
| picornavirus polyprotein + H2O | cleavage specificity, cleavage at Glx-Gly, where Gly can be replaced by Ser, Thr, Ala, Val or Met, other picornaviruses than poliovirus | Foot-and-mouth disease virus | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | cleavage specificity, cleavage at Glx-Gly, where Gly can be replaced by Ser, Thr, Ala, Val or Met, other picornaviruses than poliovirus | Enterovirus C | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | cleavage specificity, cleavage at Glx-Gly, where Gly can be replaced by Ser, Thr, Ala, Val or Met, other picornaviruses than poliovirus | Encephalomyocarditis virus | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | cleavage specificity, cleavage at Glx-Gly, where Gly can be replaced by Ser, Thr, Ala, Val or Met, other picornaviruses than poliovirus | enterovirus | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | cleavage specificity, cleavage at Glx-Gly, where Gly can be replaced by Ser, Thr, Ala, Val or Met, other picornaviruses than poliovirus | Hepatovirus A | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | cleavage specificity, cleavage at Glx-Gly, where Gly can be replaced by Ser, Thr, Ala, Val or Met, other picornaviruses than poliovirus | coxsackievirus | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | cleavage specificity, cleavage at Glx-Gly, where Gly can be replaced by Ser, Thr, Ala, Val or Met, other picornaviruses than poliovirus | Enterovirus E | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | cleavage specificity, cleavage at Glx-Gly, where Gly can be replaced by Ser, Thr, Ala, Val or Met, other picornaviruses than poliovirus | echovirus | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | cleavage specificity, cleavage at Glx-Gly, where Gly can be replaced by Ser, Thr, Ala, Val or Met, other picornaviruses than poliovirus | picornaviridae | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | involved in proteolytic processing of virus polyprotein | Foot-and-mouth disease virus | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | involved in proteolytic processing of virus polyprotein | Enterovirus C | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | involved in proteolytic processing of virus polyprotein | Encephalomyocarditis virus | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | involved in proteolytic processing of virus polyprotein | enterovirus | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | involved in proteolytic processing of virus polyprotein | Hepatovirus A | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | involved in proteolytic processing of virus polyprotein | coxsackievirus | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | involved in proteolytic processing of virus polyprotein | Enterovirus E | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | involved in proteolytic processing of virus polyprotein | echovirus | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | involved in proteolytic processing of virus polyprotein | picornaviridae | hydrolyzed picornavirus polyprotein | - |
? | |
| poliovirus P1 precursor polyprotein + H2O | - |
Enterovirus C | capsid proteins | - |
? | |
| poliovirus polyprotein + H2O | exclusive cleavage site: Gln-Gly | Enterovirus C | hydrolyzed poliovirus polyprotein | - |
? | |
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