Any feedback?
Literature summary for 3.4.22.26 extracted from
- Effect of cancer procoagulant (CP) on the growth and adhesion of MCF-7 cells to vitronectin in vitro (2005), Cancer Lett., 222, 89-94.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| E64 | specific inhibition | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| factor X + H2O | Homo sapiens | activation | factor Xa | - |
? | |
| additional information | Homo sapiens | the enzyme is able to stimulate blood platelet adhesion to fibrinogen and collagen, which can also play a role in metastatic spread of cancer as well as primary tumor growth | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| native enzyme from amniochorion membranes and from MCF-7 cells by ion exchange chromatographical steps to homogeneity | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| amniochorion | - |
Homo sapiens | - |
| breast cancer cell | - |
Homo sapiens | - |
| MCF-7 cell | breast cancer cell line | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| factor X + H2O | activation | Homo sapiens | factor Xa | - |
? | |
| additional information | the enzyme is able to stimulate blood platelet adhesion to fibrinogen and collagen, which can also play a role in metastatic spread of cancer as well as primary tumor growth | Homo sapiens | ? | - |
? | |
| additional information | the enzyme is a cysteine protease, the enzyme mediates growth and adhesion of MCF-7 cancer cells to vitronectin in vitro | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CP | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | - |
assay at | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
