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Literature summary for 3.4.22.2 extracted from

  • Panicker, S.; Borgia, J.; Fhied, C.; Mikecz, K.; Oegema, T.R.
    Oral glucosamine modulates the response of the liver and lymphocytes of the mesenteric lymph nodes in a papain-induced model of joint damage and repair (2009), Osteoarthritis Cartilage, 17, 1014-1021.
    View publication on PubMed

Application

Application Comment Organism
medicine study wether glucosamine modulates the immune and inflammatory responses to joint injury in organs proximal to glucosamine absorption using a papin-injected knee mouse model. Papain significantly degrades the proteoglycans in the injected knees by 2 days. Cartilage proteoglycan content is significantly higher in glucosamine-treated, papain-injected knees at Day 14. The peak concentration of serum pro-inflammatory cytokines occurrs earlier and decreases sooner in the injected, glucosamine-supplemented mice Carica papaya

Organism

Organism UniProt Comment Textmining
Carica papaya
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