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Literature summary for 3.4.22.16 extracted from

  • Jevnikar, Z.; Rojnik, M.; Jamnik, P.; Doljak, B.; Fonovic, U.P.; Kos, J.
    Cathepsin H mediates the processing of talin and regulates migration of prostate cancer cells (2013), J. Biol. Chem., 288, 2201-2209.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.16

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-
PC-3 cell
-
 Homo sapiens
-
prostate cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens L-Arg + 7-amino-4-methylcoumarin
-
 ?
talin + H2O cathepsin H cleaves the N-terminus of the talin F0 head domain Homo sapiens ?
-
 ?
VALSLKISIGNVVKTMQFEPST + H2O the peptide mimicks the N-terminus of the talin F0 head domain Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
CTSH
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction specific inhibition of cathepsin H increases the activation of alphabeta3-integrin on PC-3 cells Homo sapiens
physiological function cathepsin H mediates the processing of talin and regulates migration of prostate cancer cells Homo sapiens