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Literature summary for 3.4.22.15 extracted from

  • Yang, C.; Lin, X.W.; Xu, W.H.
    Cathepsin L participates in the remodeling of the midgut through dissociation of midgut cells and activation of apoptosis via caspase-1 (2017), Insect Biochem. Mol. Biol., 82, 21-30 .
    View publication on PubMed
Search for more literature for 3.4.22.15

Cloned(Commentary)

Cloned (Comment) Organism
real-time PCR enzyme expression analysis, enzyme in vitro translation Helicoverpa armigera

Inhibitors

Inhibitors Comment Organism Structure
CLIK148 cathepsin L-specific inhibitor Helicoverpa armigera
E64d
-
 Helicoverpa armigera

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Helicoverpa armigera
-
-

Organism

Organism UniProt Comment Textmining
Helicoverpa armigera B9UCR2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BCIRL-HZ-AM1 cell
-
 Helicoverpa armigera
-
epithelium
-
 Helicoverpa armigera
-
larva expression pattern and proteolytic activity of Har-CatL in the larval midgut also during metamorphosis, immunohistochemic analysis, overview Helicoverpa armigera
-
midgut
-
 Helicoverpa armigera
-
additional information expression and activity of Helicoverpa armigera cathepsin L (Har-CatL) are high in the midgut at the mid-late stage of the 6th-instar larvae and are responsive to the upstream hormone ecdysone. Developmental changes in Helicoverpa armigera cathepsin L (CatL) mRNA and protein, proteolytic activity, overview Helicoverpa armigera
-

Synonyms

Synonyms Comment Organism
CathL
-
 Helicoverpa armigera
CatL
-
 Helicoverpa armigera
Har-CatL
-
 Helicoverpa armigera

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Helicoverpa armigera

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.4
-
 assay at Helicoverpa armigera

Expression

Organism Comment Expression
Helicoverpa armigera Har-CatL can be upregulated by hormone 20-hydroxyecdysone up

General Information

General Information Comment Organism
physiological function cathepsin L participates in the remodeling of the midgut through dissociation of midgut cells and activation of apoptosis via caspase-1. Har-CatL can cleave pro-caspase-1 into the mature peptide, caspase-1 activity is regulated by Har-CatL. Enzyme Har-CatL regulates the dissociation and apoptosis of the larval midgut epithelium for midgut remodeling. Har-CatL-like expression is involved in midgut metamorphosis via degradation of intracellular and extracellular proteins Helicoverpa armigera