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Literature summary for 3.4.22.15 extracted from

  • Korenc, M.; Lenarcic, B.; Novinec, M.
    Human cathepsin L, a papain-like collagenase without proline specificity (2015), FEBS J., 282, 4328-4340 .
    View publication on PubMed
Search for more literature for 3.4.22.15

Inhibitors

Inhibitors Comment Organism Structure
soluble type I collagen inhibitory against cathepsin L, Ki is 0.36 mg/ml, collagen is also a substrate for the enzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P07711
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
 ?
additional information human cathepsin L shows no proline specificity, but collagenolytic activity. Cathepsin L also is a strong gelatinase. Comparison with cathepsin K, overview Homo sapiens ?
-
 ?
soluble type I collagen + H2O kinetics of collagen binding to cathepsin L, overview. The enzyme cleaves after residue Gln24, the recognition sequence is Gly-Phe-Gln-/-Gly-Pro-Pro (corresponding to positions P3 to P3') Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
cathepsin L1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
28
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
-
 Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
5.5 6.8 the activity is higher at pH 5.5 compared to pH 6.8 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information inhibition kinetics of collagen with cathepsin L, overview Homo sapiens