Literature summary for 3.4.22.15 extracted from

Pranjol, M.Z.I.; Gutowski, N.J.; Hannemann, M.; Whatmore, J.L.
Cathepsin L induces proangiogenic changes in human omental microvascular endothelial cells via activation of the ERK1/2 pathway (2019), Curr. Cancer Drug Targets, 19, 231-242 .

Search for more literature for 3.4.22.15

Inhibitors

Inhibitors	Comment	Organism	Structure
FY-CHO	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	the enzyme is secreted	Homo sapiens	-	-
lysosome	-	Homo sapiens	5764	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P07711	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
epithelial ovarian cancer cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Z-Val-Val-Arg-AMC + H2O	a cathepsin L-specific substrate	Homo sapiens	Z-Val-Val-Arg + 7-amino-4-methylcoumarin	-	?

Synonyms

Synonyms	Comment	Organism
cathepsin L1	-	Homo sapiens
CathL	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	CathL acts as an extracellular ligand and plays an important pro-angiogenic, and thus pro-metastatic, role during epithelial ovarian cancer metastasis to the omentum, by activating the omental microvasculature	Homo sapiens
physiological function	cathepsin L (CathL) is a cysteine endopeptidase, that physiologically plays an important role in degrading endocytosed proteins as well as intracellular proteins. Cathepsin L induces proangiogenic changes in human omental microvascular endothelial cells via activation of the ERK1/2 pathway. Epithelial ovarian cancer (EOC) cells secrete a range of factors with potential pro-angiogenic activity, in disease-relevant human omental microvascular endothelial cells (HOMECs), including the lysosomal protease cathepsin L (CathL), potential pro-proliferative and pro-migratory effects of CathL in HOMECs and the activated signalling pathways. CathL activates the proliferative kinases ERK1/2 and AKT	Homo sapiens

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Release 2023.1 (January 2023)