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Literature summary for 3.4.22.15 extracted from

  • Shivanna, V.; Kim, Y.; Chang, K.O.
    Endosomal acidification and cathepsin L activity is required for calicivirus replication (2014), Virology, 464-465, 287-295.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine treatment with cathepsin L inhibitors significantly reduces the replication of caliciviruses feline calicivirus
medicine treatment with cathepsin L inhibitors significantly reduces the replication of caliciviruses Murine norovirus 1
medicine treatment with cathepsin L inhibitors significantly reduces the replication of caliciviruses Porcine enteric sapovirus

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-Phe-Tyr-CHO
-
feline calicivirus
benzyloxycarbonyl-Phe-Tyr-CHO
-
Murine norovirus 1
benzyloxycarbonyl-Phe-Tyr-CHO
-
Porcine enteric sapovirus
MDL28170
-
feline calicivirus
MDL28170
-
Murine norovirus 1
MDL28170
-
Porcine enteric sapovirus
additional information not inhibited by CA074Me feline calicivirus
additional information not inhibited by CA074Me Murine norovirus 1
additional information not inhibited by CA074Me Porcine enteric sapovirus

Organism

Organism UniProt Comment Textmining
feline calicivirus
-
-
-
Murine norovirus 1
-
-
-
Porcine enteric sapovirus
-
-
-

General Information

General Information Comment Organism
physiological function cathepsin L activity is required for calicivirus replication feline calicivirus
physiological function cathepsin L activity is required for calicivirus replication Murine norovirus 1
physiological function cathepsin L activity is required for calicivirus replication Porcine enteric sapovirus