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Literature summary for 3.4.22.15 extracted from

  • Hook, V.; Funkelstein, L.; Wegrzyn, J.; Bark, S.; Kindy, M.; Hook, G.
    Cysteine cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimers disease (2012), Biochim. Biophys. Acta, 1824, 89-104.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.15

Inhibitors

Inhibitors Comment Organism Structure
CLIK-148 specific inhibitor of cathepsin L Mus musculus
E-64
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
secretory vesicle
-
 Mus musculus 99503
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
BAM-22P + H2O Mus musculus
-
 (Met)enkephalin + ?
-
 ?
Cholecystokinin + H2O Mus musculus
-
 ?
-
 ?
chromogranin A + H2O Mus musculus
-
 catestatin
-
 ?
pro-dynorphin + H2O Mus musculus
-
 ?
-
 ?
pro-enkephalin + H2O Mus musculus
-
 enkephalin + ?
-
 ?
Pro-opiomelanocortin + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
BAM-22P + H2O
-
 Mus musculus (Met)enkephalin + ?
-
 ?
Cholecystokinin + H2O
-
 Mus musculus ?
-
 ?
chromogranin A + H2O
-
 Mus musculus catestatin
-
 ?
pro-dynorphin + H2O
-
 Mus musculus ?
-
 ?
pro-enkephalin + H2O
-
 Mus musculus enkephalin + ?
-
 ?
Pro-opiomelanocortin + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
CatL
-
 Mus musculus

General Information

General Information Comment Organism
malfunction in cathepsin L knockou mice, brain levels of (Met)enkephalin are reduced to 44%, brain levels of neuropeptide Y are reduced to 22%, brain levels of cholecystokinin are reduced to 75%, brain levels of dynorphin A are reduced to 25% , brain levels of dynorphin B are reduced to 17%, brain levels of alpha-neoendorphin are reduced to 10%, brain levels of adrenocorticotropin hormone are reduced to 23%, brain levels of beta-endorphin are reduced to 18%, and brain levels of alpha-MSH are reduced to 7% of the wild type level Mus musculus
physiological function cathepsin L in secretory vesicles functions as a key protease for proteolytic processing of proneuropeptides (including enkephalin, neuropeptide Y, dynorphins, cholecystokinin, and others) and prohormones into active neuropeptides that are released to mediate cell-cell communication in the nervous system for neurotransmission. Cathepsin L is a key protease responsible for cholecystokinin 8 production in brain Mus musculus