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Literature summary for 3.4.22.15 extracted from

  • Beinfeld, M.C.; Funkelstein, L.; Foulon, T.; Cadel, S.; Kitagawa, K.; Toneff, T.; Reinheckel, T.; Peters, C.; Hook, V.
    Cathepsin L plays a major role in cholecystokinin production in mouse brain cortex and in pituitary AtT-20 cells: protease gene knockout and inhibitor studies (2009), Peptides, 30, 1882-1891.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
CLIK-148 specific cathepsin L inhibitor Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
27000
-
 mature cathepsin L, SDS-PAGE Mus musculus
40000
-
 pro-cathepsin L, SDS-PAGE Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
AtT-20 cell
-
 Mus musculus
-
brain cortex
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
CatL
-
 Mus musculus

General Information

General Information Comment Organism
malfunction in cathepsin L knockout mice, cholecystokinin 8 levels are substantially reduced in brain cortex by an average of 75% Mus musculus
physiological function cathepsin L functions as a major protease responsible for cholecystokinin 8 production in mouse brain cortex, and participates with prohormone convertase 1/3 for cholecystokinin 8 production in pituitary cells Mus musculus