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Literature summary for 3.4.22.15 extracted from

  • Ceru, S.; Konjar, S.; Maher, K.; Repnik, U.; Krizaj, I.; Bencina, M.; Renko, M.; Nepveu, A.; Zerovnik, E.; Turk, B.; Kopitar-Jerala, N.
    Stefin B interacts with histones and cathepsin L in the nucleus (2010), J. Biol. Chem., 285, 10078-10086.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.15

Inhibitors

Inhibitors Comment Organism Structure
cystatin B cystatin B (stefin B) plays an important role in regulating the proteolytic activity of cathepsin L in the nucleus by protecting the CUX1 transcription factor and probably other substrates from proteolytic cleavage by cathepsin L Homo sapiens
E-64
-
 Homo sapiens
additional information histones do not inhibit cathepsin L activity even at a 100fold molar excess (0.00215 mM histone concentration) Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CUX1 transcription factor + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
T-98G cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-L-Phe-L-Arg-4-nitroanilide + H2O
-
 Homo sapiens benzyloxycarbonyl-L-Phe-L-Arg + 4-nitroaniline
-
 ?
CUX1 transcription factor + H2O
-
 Homo sapiens ?
-
 ?